Potential Relationship between Clinical Significance and Serum Exosomal miRNAs in Patients with Multiple Myeloma

• Published in: BioMed research international Vol. 2019; no. 2019; pp. 1 - 8
• Main Authors: Wang, Hui-juan, Geng, Chuan-ying, Li, Yan-chen, Zhang, Zhi-yao, Chen, Wen-ming
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2019; Hindawi; Hindawi Limited
• Subjects: Biomedical research; Biotechnology; Clinical significance; Creatinine; Exosomes; Gene expression; Interleukin 6; MicroRNAs; miRNA; Multiple myeloma; Pathogenesis; Patients; Studies; β2 Microglobulin; United States > US; Germany
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2019/1575468

This study evaluated the potential relationship between exosomal miRNAs and clinical symptoms in patients with multiple myeloma (MM). Forty-eight newly diagnosed myeloma patients and sixteen normal donors were enrolled in the study. The results showed that the relative expression levels of let-7c-5p, let-7d-5p, miR-140-3p, miR-185-5p, and miR-425-5p in the exosomes of MM patients were significantly lower than those of healthy controls. Furthermore, there were significant differences in the clinical characteristics of myeloma, such as kidney damage, while the expression levels of the same miRNA in exosomes and serum are not correlated. The expression of exosomal miRNA is related to the expression levels of clinical feature-related factors, such as creatinine, β2-microglobulin, β-CTX, and IL-6 in serum. Establishing this relationship could contribute to understanding the pathogenesis of MM.