In Vitro Alpha-glucosidase Inhibitory Effect of Zn(II) Complex with 6-Methyl-2-picolinmethylamide

We found alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide (6mpa-ma) which showed the highest blood glucose lowering effect in Zn(II) complexes with picolinamide derivatives in KK-Ay mice. The Zn(II) complex showed strong alpha-glucosidase inhibitory activity g...

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Published inChemical & pharmaceutical bulletin Vol. 53; no. 4; pp. 451 - 452
Main Authors Ueda, Eriko, Yoshikawa, Yutaka, Sakurai, Hiromu, Kojima, Yoshitane, Kajiwara, Naemi M.
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.04.2005
Japan Science and Technology Agency
Subjects
6-methyl-2-picolinmethylamide
alpha-glucosidase
Animals
Chlorides
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - pharmacology
Glycoside Hydrolase Inhibitors
Hypoglycemic Agents - chemical synthesis
Hypoglycemic Agents - pharmacology
Mice
Organometallic Compounds - chemical synthesis
Organometallic Compounds - pharmacology
Pyridines - chemical synthesis
Pyridines - pharmacology
Zinc Compounds
Zn(II) complex
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Summary:We found alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide (6mpa-ma) which showed the highest blood glucose lowering effect in Zn(II) complexes with picolinamide derivatives in KK-Ay mice. The Zn(II) complex showed strong alpha-glucosidase inhibitory activity greater by about eighty times (substrate: maltose) and forty times (substrate: sucrose) compared with acarbose.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.53.451