Aurantiogliocladin inhibits biofilm formation at subtoxic concentrations
Infections where pathogens are organized in biofilms are difficult to treat due to increased antibiotic resistances in biofilms. To overcome this limitation new approaches are needed to control biofilms. One way is to screen natural products from organisms living in a wet environment. The rational i...
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Published in | AIMS microbiology Vol. 3; no. 1; pp. 50 - 60 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
AIMS Press
01.01.2017
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Subjects | |
Online Access | Get full text |
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Summary: | Infections where pathogens are organized in biofilms are difficult to treat due to increased antibiotic resistances in biofilms. To overcome this limitation new approaches are needed to control biofilms. One way is to screen natural products from organisms living in a wet environment. The rational is that these organisms are preferentially threatened by biofilm formation and may have developed strategies to control pathogens in these biofilms. In a screen of fungal isolates obtained from the Harz mountains in Germany several strains have been found producing compounds for the inhibition of biofilms. One of these strains has been identified as
producing aurantiogliocladin. Biological tests showed aurantiogliocladin as a weak antibiotic which was active against
but not
. Aurantiogliocladin could also inhibit biofilm formation of several of the tested bacterial strains. This inhibition, however, was never complete but biofilm inhibition activity was also found at concentrations below the minimal inhibitory concentrations, e. g.
with a MIC of 128 µg mL
showed at 32 µg mL
still 37% biofilm inhibition. In agreement with this finding was the observation that aurantiogliocladin was bacteriostatic for the tested bacteria but not bactericidal. Because several closely related toluquinones with different antibiotic activities have been reported from various fungi screening of a chemical library of toluquinones is suggested for the improvement of biofilm inhibition activities. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2471-1888 2471-1888 |
DOI: | 10.3934/microbiol.2017.1.50 |