Circulating fibrosis markers, eosinophil cationic protein and eosinophil protein X in patients with Wuchereria bancrofti infection: association with clinical status

• Published in: Parasite (Paris) Vol. 13; no. 2; pp. 165 - 170
• Main Authors: Esterre, P., Plichart, C., Huin-Blondey, M.O., Nguyen, L.N., Hartmann, D., Guerret, S., Reimert, C.M., Ricard-Blum, S.
• Format: Journal Article
• Language: English
• Published: Paris EDP Sciences 01.06.2006; Princeps
• Subjects: Adult; Animals; Biochemistry, Molecular Biology; Biological and medical sciences; Biomarkers - blood; Diseases caused by nematodes; Elephantiasis, Filarial - blood; Elephantiasis, Filarial - parasitology; Elephantiasis, Filarial - pathology; Enzyme-Linked Immunosorbent Assay; Eosinophil Cationic Protein - blood; eosinophil proteins; Eosinophil-Derived Neurotoxin - blood; Female; Fibrosis; fibrosis markers; Filariases; Filariasis - blood; Filariasis - parasitology; Filariasis - pathology; filariose lymphatique; French Polynesia; Helminthic diseases; Humans; Immunologic Factors - blood; Infectious diseases; Life Sciences; Lymphatic filariases; lymphatic filariasis; Male; marqueurs de fibrose; Medical sciences; Middle Aged; Parasitic diseases; Polynesia; Polynésie Française; protéines de l’éosinophile; Wuchereria bancrofti - immunology; Polynesia; Oceania; French Polynesia; Human; Cationic protein; Wuchereria bancrofti; Parasitosis; Marker; Helminthiasis; Eosinophil; Infection; Nematode disease; Fibrosis; Helmintha; Nemathelminthia; Filariosis; Invertebrata; Nematoda
• ISSN: 1252-607X; 1776-1042
• DOI: 10.1051/parasite/2006132165

We measured the concentrations of several circulating fibrosis markers (type I collagen I, type III procollagen, hyaluronan) and eosinophil granule proteins (ECP and EPX) in lymphatic filariasis patients to investigate their relationship with clinical, parasitological and immunological data. This study was conducted in Polynesian patients with various stages of the disease (acute lymphangitis, chyluria, hydrocoele, elephantiasis), a closely related microbial lymphangitis and endemic controls. We observed modifications of the different markers in this pathology. Serum type I collagen and PIIINP were decreased. Serum hyaluronan, linked to perilymphatic granulomatous inflammation, was significantly increased in acute lymphangitis and elephantiasis patients. Serum ECP was also increased, at the limit of significance in our sample, in elephantiasis patients. These two last markers, already validated in another helminth disease, schistosomiasis, have potential interest in terms of follow-up of morbidity in these parasitic diseases. Les dosages d’un certain nombre de marqueurs circulants de fibrose (collagène I, procollagène III, hyaluronane), déjà validés sur plusieurs fibroses d’origine parasitaire, et de protéines des granules de l’éosinophile (protéines ECP et EPX), impliquées dans l’immunité anti-larves, ont été réalisés chez des patients polynésiens présentant différents stades de filariose lymphatique (adénolymphangite aigue, chylurie, hydrocèle, éléphantiasis). Ces résultats ont été comparés avec ceux observés dans une lymphangite microbienne cliniquement très proche (érysipèle) et des contrôles endémiques. Deux marqueurs potentiels de morbidité, déjà validés en matière de bilharziose, ont été identifiés : le hyaluronane sérique et la protéine ECP ; le premier de manière significative aussi bien dans les lymphangites aiguës que dans les éléphantiasis chroniques.