Development of Prognostic Indicator Based on Autophagy-Related lncRNA Analysis in Colon Adenocarcinoma

• Published in: BioMed research international Vol. 2020; no. 2020; pp. 1 - 14
• Main Authors: Chen, Xin-lin, Chen, Zheng, Chen, Li-xia, Tang, Shuting, Cai, Zheyou, Li, Hui-biao, Zhang, Shijing, Zhou, Weige, Lang, Jian-ying
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc
• Subjects: Adenocarcinoma; Adenocarcinoma - genetics; Adenocarcinoma - pathology; Autophagy; Autophagy - genetics; Biomarkers; Biomarkers, Tumor - genetics; Cancer therapies; CD27 antigen; Chemotherapy; Colon; Colon - pathology; Colonic Neoplasms - genetics; Colonic Neoplasms - pathology; Colorectal cancer; Disease; Encyclopedias; Female; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Gene Ontology; Gene Regulatory Networks - genetics; Genes; Genomes; Humans; Male; Medical prognosis; Metabolism; MicroRNAs; Phagocytosis; Prognosis; Regression analysis; Ribonucleic acid; Risk; Risk groups; RNA; RNA, Long Noncoding - genetics
• ISSN: 2314-6133; 2314-6141; 2314-6141
• DOI: 10.1155/2020/9807918

There were no systematic researches about autophagy-related long noncoding RNA (lncRNA) signatures to predict the survival of patients with colon adenocarcinoma. It was necessary to set up corresponding autophagy-related lncRNA signatures. The expression profiles of lncRNAs which contained 480 colon adenocarcinoma samples were obtained from The Cancer Genome Atlas (TCGA) database. The coexpression network of lncRNAs and autophagy-related genes was utilized to select autophagy-related lncRNAs. The lncRNAs were further screened using univariate Cox regression. In addition, Lasso regression and multivariate Cox regression were used to develop an autophagy-related lncRNA signature. A risk score based on the signature was established, and Cox regression was used to test whether it was an independent prognostic factor. The functional enrichment of autophagy-related lncRNAs was visualized using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. Ten prognostic autophagy-related lncRNAs (AC027307.2, AC068580.3, AL138756.1, CD27-AS1, EIF3J-DT, LINC01011, LINC01063, LINC02381, AC073896.3, and SNHG16) were identified to be significantly different, which made up an autophagy-related lncRNA signature. The signature divided patients with colon adenocarcinoma into the low-risk group and the high-risk group. A risk score based on the signature was a significantly independent factor for the patients with colon adenocarcinoma (HR=1.088, 95%CI=1.057−1.120; P<0.001). Additionally, the ten lncRNAs were significantly enriched in autophagy process, metabolism, and tumor classical pathways. In conclusion, the ten autophagy-related lncRNAs and their signature might be molecular biomarkers and therapeutic targets for the patients with colon adenocarcinoma.