Potential of Gene and Cell Therapy for Inner Ear Hair Cells

Sensorineural hearing loss is caused by the loss of sensory hair cells (HCs) or a damaged afferent nerve pathway to the auditory cortex. The most common option for the treatment of sensorineural hearing loss is hearing rehabilitation using hearing devices. Various kinds of hearing devices are availa...

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Bibliographic Details
Published inBioMed research international Vol. 2018; no. 2018; pp. 1 - 11
Main Authors Lee, Min Young, Park, Yong-Ho
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2018
Hindawi
Hindawi Limited
Subjects
Animals
Clustered Regularly Interspaced Short Palindromic Repeats
Cochlea
Cortex (auditory)
CRISPR
Gene expression
Gene therapy
Genetic Therapy
Genome editing
Genomes
Hair
Hair cells
Hair Cells, Auditory
Hair Cells, Auditory, Inner
Hearing aids
Hearing loss
Hearing Loss, Sensorineural - therapy
Hearing protection
Humans
Inner ear
Medical research
Medical treatment
Mice
Otolaryngology
Otology
Rats
Regeneration
Rehabilitation
Review
Sensory neurons
Somatosensory cortex
Stem Cell Transplantation
Stem cells
Transplants & implants
Vectors (Biology)
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Summary:Sensorineural hearing loss is caused by the loss of sensory hair cells (HCs) or a damaged afferent nerve pathway to the auditory cortex. The most common option for the treatment of sensorineural hearing loss is hearing rehabilitation using hearing devices. Various kinds of hearing devices are available but, despite recent advancements, their perceived sound quality does not mimic that of the “naïve” cochlea. Damage to crucial cochlear structures is mostly irreversible and results in permanent hearing loss. Cochlear HC regeneration has long been an important goal in the field of hearing research. However, it remains challenging because, thus far, no medical treatment has successfully regenerated cochlear HCs. Recent advances in genetic modulation and developmental techniques have led to novel approaches to generating HCs or protecting against HC loss, to preserve hearing. In this review, we present and review the current status of two different approaches to restoring or protecting hearing, gene therapy, including the newly introduced CRISPR/Cas9 genome editing, and stem cell therapy, and suggest the future direction.
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Academic Editor: Vickram Ramkumar
ISSN:2314-6133
2314-6141
DOI:10.1155/2018/8137614