Diabetic CKD/ESRD 2010: A Progress Report?

• Published in: Seminars in dialysis Vol. 23; no. 2; pp. 129 - 133
• Main Author: Williams, Mark E.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.03.2010
• Subjects: Diabetic Nephropathies - epidemiology; Diabetic Nephropathies - ethnology; Diabetic Nephropathies - therapy; Disease Progression; Global Health; Humans; Incidence; Kidney Failure, Chronic - epidemiology; Kidney Failure, Chronic - ethnology; Kidney Failure, Chronic - therapy; Prevalence; Prognosis; Renal Replacement Therapy; Risk Factors; United States - epidemiology; United States
• ISSN: 0894-0959; 1525-139X
• DOI: 10.1111/j.1525-139X.2009.00698.x

Both in the United States and many regions of the world, chronic kidney disease and end‐stage renal disease (ESRD) in patients with diabetes mellitus have reached epidemic proportions in recent years. The large prevalent diabetic ESRD population in the US involves remarkable risk in African Americans and an increasing population of elderly diabetic patients, including many octogenarians. In the US and globally, over 90% of diabetic ESRD patients have type 2 diabetes. The multinational epidemic of diabetic ESRD has been linked to increases in the prevalence of diabetes in many populations, related to obesity, ageing, and physical inactivity. It is anticipated that the worldwide prevalence of diabetes over the next 20 years will reach a level twice that of the year 2000. The excessive morbidity and mortality of the diabetic ESRD population are well documented. However, the growth in incidence and prevalence rates for diabetic ESRD has remained somewhat stable in the US in recent years, and new data suggest that the incidence of ESRD expressed per diabetic population may finally be declining, suggesting that proven therapies are making “progress on progression.”