Prediagnostic level of fatty acids in serum phospholipids: Ω‐3 and Ω‐6 fatty acids and the risk of prostate cancer

• Published in: International journal of cancer Vol. 71; no. 4; pp. 545 - 551
• Main Authors: Harvei, Sverre, Bjerve, Kristian S., Tretli, Steinar, Jellum, Egil, Robsahm, Trude E., Vatten, Lars
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 16.05.1997; Wiley-Liss
• Subjects: alpha-Linolenic Acid - adverse effects; alpha-Linolenic Acid - blood; Biological and medical sciences; Case-Control Studies; Dietary Fats - adverse effects; Dietary Fats - pharmacokinetics; Fatty Acids - blood; Fatty Acids, Omega-3 - blood; Fatty Acids, Omega-6; Fatty Acids, Unsaturated - blood; Humans; Incidence; Linoleic Acid; Linoleic Acids - blood; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Norway - epidemiology; Phospholipids - blood; Prostatic Neoplasms - blood; Prostatic Neoplasms - epidemiology; Prostatic Neoplasms - etiology; Risk Factors; Single-Blind Method; Tumors of the urinary system; Urinary tract. Prostate gland; Norway; Human; Correlation; Urinary system disease; Linolenic acid; Prostate disease; Diet; Risk factor; Polyunsaturated fatty acid; Male; Malignant tumor; Male genital diseases; Prostate
• ISSN: 0020-7136; 1097-0215
• DOI: 10.1002/(SICI)1097-0215(19970516)71:4<545::AID-IJC7>3.0.CO;2-U

Ecological and case‐control studies have demonstrated a positive correlation between consumption of fat and the risk of prostate cancer. Two recent human studies have focused on α‐linolenic acid as a risk factor for prostate cancer. Animal experiments have shown that dietary ω‐6 polyunsaturated fatty acids have generally stimulated tumour development, whereas ω‐3 polyunsaturated fatty acids have diminished it. The aim of our study was to investigate the association between these fatty acids and the subsequent risk of prostate cancer. Blood donors to the Janus serum data bank in Norway, who later developed prostate cancer, were matched to blood donors without prostate cancer (141 matched sets); the proportional level of fatty acids measured before diagnosis in the donors' serum was examined. The risk of later prostate cancer was analysed by conditional logistic regression. Increasing risk for prostate cancer was found with increasing quartiles of palmitoleic, palmitic and α‐linolenic acid. An inverse risk association was found with increasing levels of tetracosanoic acid, for the ratios of linoleic to α‐linolenic acid and arachidonic to eicosapentaenoic acid. There was no clear association between the risk effect of total ω‐3 and total ω‐6 fatty acids. There were no indications of a relationship between fatty acids and more aggressive cancers. Our results verify recent findings of a positive association between α‐linolenic acid and a negative association between the ratio of linoleic to α‐linolenic acid and the risk of prostate cancer. Int. J. Cancer 71:545‐551, 1997. © 1997 Wiley‐Liss, Inc.