Symptomatic reinfection of SARS‐CoV‐2 with spike protein variant N440K associated with immune escape

This report describes a case of re‐infection in an individual from South India characterized by whole genome sequencing of the virus isolated from both episodes. The analysis shows the presence of an immune escape variant N440K in the Spike protein in both episodes of infection. Incidentally, this v...

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Published inJournal of Medical Virology Vol. 93; no. 7; pp. 4163 - 4165
Main Authors Rani, Pallavali R., Imran, Mohamed, Lakshmi, Juturu V., Jolly, Bani, Jain, Abhinav, Surekha, Avileli, Senthivel, Vigneshwar, Chandrasekhar, Pulala, Divakar, Mohit K., Srinivasulu, Damam, Bhoyar, Rahul C., Vanaja, P. R., Scaria, Vinod, Sivasubbu, Sridhar
Format Journal Article Web Resource
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.07.2021
Wiley Subscription Services, Inc
John Wiley and Sons Inc
Subjects
Immune evasion
Letter to the Editor
Letters to the Editor
Severe acute respiratory syndrome coronavirus 2
Spike protein
Virology
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Summary:This report describes a case of re‐infection in an individual from South India characterized by whole genome sequencing of the virus isolated from both episodes. The analysis shows the presence of an immune escape variant N440K in the Spike protein in both episodes of infection. Incidentally, this variant was also found in a case of reinfection previously reported by us in a healthcare worker from North India
Bibliography:Pallavali R. Rani and Mohamed Imran contributed equally to this manuscript.
SourceType-Other Sources-1
ObjectType-Article-2
content type line 63
ObjectType-Correspondence-1
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.26997