Macrocyclic Helix-Threading Peptides for Targeting RNA

Hanging on by a thread: RNA‐binding macrocyclic helix‐threading peptides were synthesized by solid‐phase ring‐closing metathesis. The cyclic peptide shows improved affinity to a target RNA over its linear precursor. This compound also binds a naturally occurring precursor microRNA target and may be...

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Published inAngewandte Chemie (International ed.) Vol. 46; no. 37; pp. 7044 - 7047
Main Authors Krishnamurthy, Malathy, Simon, Kristina, Orendt, Anita M, Beal, Peter A
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 01.01.2007
WILEY-VCH Verlag
WILEY‐VCH Verlag
Wiley
Subjects
Base Sequence
Chemistry
Chemistry, Multidisciplinary
Humans
Macrocyclic Compounds - chemistry
Macrocyclic Compounds - metabolism
microRNA
Molecular Sequence Data
Molecular Structure
Nucleic Acid Conformation
peptides
Peptides - chemistry
Peptides - genetics
Peptides - metabolism
Physical Sciences
Protein Structure, Secondary
quinolines
ring-closing metathesis
RNA - chemistry
RNA - genetics
RNA - metabolism
RNA recognition
Science & Technology
SMALL MOLECULES
SOLID-PHASE SYNTHESIS
STABILITY
RNA recognition
peptides
MICRORNAS
ring-closing metathesis
INHIBITION
METHYLTHIO
microRNA
MIRNAS
ANTAGONISTS
BINDING
quinolines
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Summary:Hanging on by a thread: RNA‐binding macrocyclic helix‐threading peptides were synthesized by solid‐phase ring‐closing metathesis. The cyclic peptide shows improved affinity to a target RNA over its linear precursor. This compound also binds a naturally occurring precursor microRNA target and may be valuable for regulating microRNA function.
Bibliography:http://dx.doi.org/10.1002/anie.200702247
P.A.B. would like to acknowledge support from the National Institutes of Health (USA) (GM057214). The computational resources for this project have been provided by the National Institutes of Health (Grant number NCRR 1 S10 RR17214-01) on the Arches Metacluster, administered by the University of Utah Center for High Performance Computing.
ArticleID:ANIE200702247
National Institutes of Health - No. GM057214
National Institutes of Health - No. NCRR 1 S10 RR17214-01
ark:/67375/WNG-C39HT87V-2
istex:CFAE21646E7DDB178EF149ACD2A466F0FF98F0FD
P.A.B. would like to acknowledge support from the National Institutes of Health (USA) (GM057214). The computational resources for this project have been provided by the National Institutes of Health (Grant number NCRR 1 S10 RR17214‐01) on the Arches Metacluster, administered by the University of Utah Center for High Performance Computing.
Medline
NIH RePORTER
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200702247