A unique case of der(11)t(11;22),-22 arising from 3:1 segregation of a maternal t(11;22) in a family with co-segregation of the translocation and breast cancer

• Published in: Prenatal diagnosis Vol. 25; no. 8; pp. 683 - 686
• Main Authors: Jobanputra, Vaidehi, Chung, Wendy K., Hacker, April M., Emanuel, Beverly S., Warburton, Dorothy
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.08.2005; Wiley
• Subjects: 22; 3 : 1 segregation; Abortion, Habitual - genetics; Adult; Biological and medical sciences; breast cancer; Breast Neoplasms - genetics; Chromosome aberrations; Chromosome Banding; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 22; Female; Gynecology. Andrology. Obstetrics; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Management. Prenatal diagnosis; Medical genetics; Medical sciences; Meiosis; Monosomy - genetics; Pregnancy; Pregnancy. Fetus. Placenta; t(11;22); tertiary monosomy; Translocation, Genetic; Chromosomal aberration; Family study; Segregation; Prenatal Diagnosis; tertiary monosomy; Th1 lymphocyte; Aneuploidy; 3:1 segregation; Breast cancer; Malignant tumor; t(11;22); Case study; Mammary gland diseases; Mother; Abnormal chromosome G22; Cytogenetics; Abnormal chromosome; Abnormal chromosome C11; Monosomy; Chromosome translocation
• ISSN: 0197-3851; 1097-0223
• DOI: 10.1002/pd.1196

Objective To report the first tertiary monosomy in a pregnancy loss to a female t(11;22) carrier. Methods The patient was a 34‐year‐old G10P1 female known to have a balanced translocation t(11;22)(q23;q11.2). She had one female livebirth (a translocation carrier) and eight miscarriages. Five female relatives known to be translocation carriers had a history of breast cancer, three of them premenopausally. The patient herself had a malignant melanoma. Results During the 10th pregnancy, ultrasound showed a viable embryo at 6 weeks of gestation, but loss of embryonic heartbeat by 7.5 weeks. Culture of the products of conception at 8 weeks of gestation showed the karyotype: 46,XY,+2,der(11)t(11;22)(q23;q11.2)mat,‐22[4]/45,XY,der(11)t(11;22)(q23;q11.2)mat,‐22[4], resulting from fertilization of the maternal 3:1 segregation product containing only the der(11) by a normal gamete. Subsequently, she became pregnant with a normal 46,XX fetus. FISH analysis indicated that the breakpoints on 11q and 22q in the patient were in the previously described region common to typical recurrent t(11;22). In addition, a nested‐PCR‐based approach showed that they were located within the same palindromic AT‐rich sequence previously described. Conclusion This case demonstrates that the tertiary monosomy resulting from the 3:1 segregation is compatible with embryonic survival into the first trimester. It is also another example of apparent association of the constitutional translocation t(11;22) and breast cancer. Copyright © 2005 John Wiley & Sons, Ltd.