Azadirachtin Story

Azadirachtin has been the subject of intensive research within the scientific community ever since its isolation from the neem tree in 1968. There are now over 1000 publications relating to this natural product which cover all aspects of structural, biological and synthetic studies. Herein, we descr...

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Published inAngewandte Chemie (International ed.) Vol. 47; no. 49; pp. 9402 - 9429
Main Authors Veitch, Gemma E, Boyer, Alistair, Ley, Steven V
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 24.11.2008
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects
antifeedants
Azadirachta - chemistry
Claisen rearrangement
epoxidation
Limonins - chemical synthesis
Limonins - chemistry
Limonins - isolation & purification
natural products
radical cyclization
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Abstract Azadirachtin has been the subject of intensive research within the scientific community ever since its isolation from the neem tree in 1968. There are now over 1000 publications relating to this natural product which cover all aspects of structural, biological and synthetic studies. Herein, we describe the worldwide synthesis efforts towards this fascinating molecule.
AbstractList Azadirachtin has been the subject of intensive research within the scientific community ever since its isolation from the neem tree in 1968. There are now over 1000 publications relating to this natural product which cover all aspects of structural, biological and synthetic studies. Herein, we describe the worldwide synthesis efforts towards this fascinating molecule.
Azadirachtin has been the subject of intensive research within the scientific community ever since its isolation from the neem tree in 1968. There are now over 1000 publications relating to this natural product which cover all aspects of structural, biological and synthetic studies. Herein, we describe the worldwide synthesis efforts towards this fascinating molecule. Long and winding road: The natural product azadirachtin (see figure) was first isolated in 1968 from the neem tree, and has been the focus of intense research efforts ever since. With numerous obstacles now overcome, the international efforts towards the total synthesis of this fascinating molecule have now achieved their long‐standing goal.
Abstract Azadirachtin has been the subject of intensive research within the scientific community ever since its isolation from the neem tree in 1968. There are now over 1000 publications relating to this natural product which cover all aspects of structural, biological and synthetic studies. Herein, we describe the worldwide synthesis efforts towards this fascinating molecule.
Author Veitch, Gemma E.
Boyer, Alistair
Ley, Steven V.
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1984; 25
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1985; 26
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1964 1964; 76 3
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1971 1971; 83 10
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1990
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Snippet Azadirachtin has been the subject of intensive research within the scientific community ever since its isolation from the neem tree in 1968. There are now over...
Abstract Azadirachtin has been the subject of intensive research within the scientific community ever since its isolation from the neem tree in 1968. There are...
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SubjectTerms antifeedants
Azadirachta - chemistry
Claisen rearrangement
epoxidation
Limonins - chemical synthesis
Limonins - chemistry
Limonins - isolation & purification
natural products
radical cyclization
Title Azadirachtin Story
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https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fanie.200802675
https://www.ncbi.nlm.nih.gov/pubmed/19031481
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