Multifunctional Magneto-Polymeric Nanohybrids for Targeted Detection and Synergistic Therapeutic Effects on Breast Cancer

Diagnosis and treatment all in one: Multifunctional magneto‐polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe2O4 nanocrystals, chemotherapeutic agents, and encapsulating amphiphilic block copolymers for targeted detection by MRI and treatment of breast cancer. See the TEM...

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Published in	Angewandte Chemie (International ed.) Vol. 46; no. 46; pp. 8836 - 8839
Main Authors	Yang, Jaemoon, Lee, Choong-Hwan, Ko, Hyun-Ju, Suh, Jin-Suck, Yoon, Ho-Geun, Lee, Kwangyeol, Huh, Yong-Min, Haam, Seungjoo
Format	Journal Article
Language	English
Published	Weinheim Wiley-VCH Verlag 01.01.2007 WILEY-VCH Verlag WILEY‐VCH Verlag
Subjects	Animals Antineoplastic Agents - therapeutic use Breast Neoplasms - drug therapy Cell Line, Tumor drug delivery Drug Delivery Systems Female Humans hybrid composites imaging agents magnetic resonance Magnetic Resonance Imaging Magnetics Mice Nanomedicine - methods Nanoparticles - therapeutic use Neoplasms, Experimental - drug therapy Polymers - therapeutic use transmission electron microscopy
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Abstract	Diagnosis and treatment all in one: Multifunctional magneto‐polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe2O4 nanocrystals, chemotherapeutic agents, and encapsulating amphiphilic block copolymers for targeted detection by MRI and treatment of breast cancer. See the TEM image (left) of an MMPN and T2‐weighted MR images (top row) and color map (bottom row) of the relaxivity R2 for NIH3T6.7 and MDA‐MB‐231 cells.
AbstractList	Diagnosis and treatment all in one: Multifunctional magneto‐polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe2O4 nanocrystals, chemotherapeutic agents, and encapsulating amphiphilic block copolymers for targeted detection by MRI and treatment of breast cancer. See the TEM image (left) of an MMPN and T2‐weighted MR images (top row) and color map (bottom row) of the relaxivity R2 for NIH3T6.7 and MDA‐MB‐231 cells.
Author	Huh, Yong-Min Yang, Jaemoon Haam, Seungjoo Ko, Hyun-Ju Lee, Kwangyeol Lee, Choong-Hwan Suh, Jin-Suck Yoon, Ho-Geun
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Notes	http://dx.doi.org/10.1002/anie.200703554 We thank Prof. Kunhong Kim at Yonsei University for the insightful discussion. This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (R15-2004-024-00000-0 and R01-2006-000-10023-0, and KOSEF 2007-8-1158), the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (0620190-1). ark:/67375/WNG-GBSK3JSK-H National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea - No. 0620190-1 ArticleID:ANIE200703554 istex:DA03B1A34C929C62D8DCC52E6ED3FA70076897BD National Core Research Center for Nanomedical Technology - No. R15-2004-024-00000-0; No. R01-2006-000-10023-0; No. KOSEF 2007-8-1158 We thank Prof. Kunhong Kim at Yonsei University for the insightful discussion. This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (R15‐2004‐024‐00000‐0 and R01‐2006‐000‐10023‐0, and KOSEF 2007‐8‐1158), the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (0620190‐1). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
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Snippet	Diagnosis and treatment all in one: Multifunctional magneto‐polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe2O4 nanocrystals,...
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SubjectTerms	Animals Antineoplastic Agents - therapeutic use Breast Neoplasms - drug therapy Cell Line, Tumor drug delivery Drug Delivery Systems Female Humans hybrid composites imaging agents magnetic resonance Magnetic Resonance Imaging Magnetics Mice Nanomedicine - methods Nanoparticles - therapeutic use Neoplasms, Experimental - drug therapy Polymers - therapeutic use transmission electron microscopy
Title	Multifunctional Magneto-Polymeric Nanohybrids for Targeted Detection and Synergistic Therapeutic Effects on Breast Cancer
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