Multifunctional Magneto-Polymeric Nanohybrids for Targeted Detection and Synergistic Therapeutic Effects on Breast Cancer

Diagnosis and treatment all in one: Multifunctional magneto‐polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe2O4 nanocrystals, chemotherapeutic agents, and encapsulating amphiphilic block copolymers for targeted detection by MRI and treatment of breast cancer. See the TEM...

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Published inAngewandte Chemie (International ed.) Vol. 46; no. 46; pp. 8836 - 8839
Main Authors Yang, Jaemoon, Lee, Choong-Hwan, Ko, Hyun-Ju, Suh, Jin-Suck, Yoon, Ho-Geun, Lee, Kwangyeol, Huh, Yong-Min, Haam, Seungjoo
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 01.01.2007
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects
Animals
Antineoplastic Agents - therapeutic use
Breast Neoplasms - drug therapy
Cell Line, Tumor
drug delivery
Drug Delivery Systems
Female
Humans
hybrid composites
imaging agents
magnetic resonance
Magnetic Resonance Imaging
Magnetics
Mice
Nanomedicine - methods
Nanoparticles - therapeutic use
Neoplasms, Experimental - drug therapy
Polymers - therapeutic use
transmission electron microscopy
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Summary:Diagnosis and treatment all in one: Multifunctional magneto‐polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe2O4 nanocrystals, chemotherapeutic agents, and encapsulating amphiphilic block copolymers for targeted detection by MRI and treatment of breast cancer. See the TEM image (left) of an MMPN and T2‐weighted MR images (top row) and color map (bottom row) of the relaxivity R2 for NIH3T6.7 and MDA‐MB‐231 cells.
Bibliography:http://dx.doi.org/10.1002/anie.200703554
We thank Prof. Kunhong Kim at Yonsei University for the insightful discussion. This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (R15-2004-024-00000-0 and R01-2006-000-10023-0, and KOSEF 2007-8-1158), the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (0620190-1).
ark:/67375/WNG-GBSK3JSK-H
National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea - No. 0620190-1
ArticleID:ANIE200703554
istex:DA03B1A34C929C62D8DCC52E6ED3FA70076897BD
National Core Research Center for Nanomedical Technology - No. R15-2004-024-00000-0; No. R01-2006-000-10023-0; No. KOSEF 2007-8-1158
We thank Prof. Kunhong Kim at Yonsei University for the insightful discussion. This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (R15‐2004‐024‐00000‐0 and R01‐2006‐000‐10023‐0, and KOSEF 2007‐8‐1158), the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (0620190‐1).
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SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200703554