Complete bone regeneration in hemophilic pseudotumor of the mandible

Hemophilic pseudotumor (HP) is rare, seen in 1–2% of patients with hemophilia, and is extremely uncommon in the mandible. A 6‐year‐old boy with moderate hemophilia A presented to our hospital with left mandibular swelling. Based on clinical and radiological findings, a tentative diagnosis of HP was...

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Published inPediatrics international Vol. 58; no. 5; pp. 406 - 408
Main Authors Otsuka, Hiroki, Ozeki, Michio, Kanda, Kaori, Hori, Tomohiro, Kawamoto, Norio, Saigo, Chiemi, Kato, Hiroki, Makita, Hiroki, Shibata, Toshiyuki, Fukao, Toshiyuki
Format Journal Article
LanguageEnglish
Published Australia Blackwell Publishing Ltd 01.05.2016
Subjects
Bone growth
bone regeneration
Bones
Coagulation factors
diagnostic imaging
factor VIII
Factor VIII deficiency
Hemophilia
Histopathology
Mandible
Patients
Pediatrics
Prophylaxis
Pseudotumors
Regeneration
mandible
hemophilia
bone regeneration
factor VIII
diagnostic imaging
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ISSN1328-8067
1442-200X
DOI10.1111/ped.12820

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Summary:Hemophilic pseudotumor (HP) is rare, seen in 1–2% of patients with hemophilia, and is extremely uncommon in the mandible. A 6‐year‐old boy with moderate hemophilia A presented to our hospital with left mandibular swelling. Based on clinical and radiological findings, a tentative diagnosis of HP was made. After factor VIII administration, the lesion was curetted and HP was confirmed on histopathology. The patient was treated with twice‐weekly factor VIII until the lesion had completely resolved and bone had regenerated at 1 year. The best treatment for HP is not established; however, appropriate initial treatment and postoperative prophylaxis are effective.
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ISSN:1328-8067
1442-200X
DOI:10.1111/ped.12820