Neuropeptide Y and its role in CNS disease and repair

• Published in: Experimental neurology Vol. 238; no. 2; pp. 265 - 272
• Main Authors: Decressac, M., Barker, R.A.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.12.2012; Elsevier
• Subjects: Animals; Biological and medical sciences; Central Nervous System Diseases - drug therapy; Central Nervous System Diseases - metabolism; Central Nervous System Diseases - pathology; Clinical Medicine; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Doublecortin Domain Proteins; Gene Expression Regulation - drug effects; Humans; Klinisk medicin; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Microtubule-Associated Proteins - metabolism; Neurodegenerative diseases; Neurogenesis; Neurogenesis - drug effects; Neurologi; Neurology; Neuropeptide Y; Neuropeptide Y - metabolism; Neuropeptide Y - pharmacology; Neuropeptide Y - therapeutic use; Neuropeptides - metabolism; Neuroprotection; Neuroprotective Agents - metabolism; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Signal Transduction - drug effects; Neuropeptide Y; Neuroprotection; Neurodegenerative diseases; Neurogenesis; Nervous system diseases; Central nervous system; Repair
• ISSN: 0014-4886; 1090-2430
• DOI: 10.1016/j.expneurol.2012.09.004

Neuropeptide Y (NPY) is widely expressed throughout the CNS and exerts a number of important physiological functions as well as playing a role in pathological conditions such as obesity, anxiety, epilepsy, chronic pain and neurodegenerative disorders. In this review, we highlight some of the recent advances in our understanding of NPY biology and how this may help explain not only its role in health and disease, but also its possible use therapeutically.