Temporal Factors Modulate Haloperidol-Induced Conditioned Catalepsy

Repeated pairings of a neutral context and the effects of haloperidol give rise to conditioned catalepsy when the context is subsequently presented in a drug-free test. In order to confirm whether this response is based on Pavlovian processes, we conducted two experiments involving two manipulations...

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Bibliographic Details
Published inFrontiers in behavioral neuroscience Vol. 15; p. 713512
Main Authors Cárcel, Lucía, De la Casa, Luis G.
Format Journal Article
LanguageEnglish
Published Lausanne Frontiers Research Foundation 02.07.2021
Frontiers Media S.A
Subjects
Animals
Catalepsy
Classical conditioning
Drug dosages
Drug testing
Experiments
Haloperidol
inter stimulus interval
Neuroscience
Psychotropic drugs
simultaneous conditioning
Unconditioned stimulus
United States > US
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Summary:Repeated pairings of a neutral context and the effects of haloperidol give rise to conditioned catalepsy when the context is subsequently presented in a drug-free test. In order to confirm whether this response is based on Pavlovian processes, we conducted two experiments involving two manipulations that affect conditioning intensity in classical conditioning procedures: time of joint exposure to the conditioned and the unconditioned stimulus, and the length of the inter-stimulus interval (ISI). The results revealed that both an increase in the length of context-drug pairings during conditioning and a reduced ISI between drug administration and context exposure increased conditioned catalepsy. These results are discussed in terms of the temporal peculiarities of those procedures that involve drugs as the unconditioned stimulus along with the role of Pavlovian conditioning in context-dependent catalepsy.
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Edited by: Jonathan L. C. Lee, University of Birmingham, United Kingdom
Reviewed by: Gavan McNally, University of New South Wales, Australia; Robert Carey, Upstate Medical University, United States
This article was submitted to Learning and Memory, a section of the journal Frontiers in Behavioral Neuroscience
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2021.713512