CSH guidelines for the diagnosis and treatment of drug-induced liver injury

• Published in: Hepatology international Vol. 11; no. 3; pp. 221 - 241
• Main Authors: Yu, Yue-cheng, Mao, Yi-min, Chen, Cheng-wei, Chen, Jin-jun, Chen, Jun, Cong, Wen-ming, Ding, Yang, Duan, Zhong-ping, Fu, Qing-chun, Guo, Xiao-yan, Hu, Peng, Hu, Xi-qi, Jia, Ji-dong, Lai, Rong-tao, Li, Dong-liang, Liu, Ying-xia, Lu, Lun-gen, Ma, Shi-wu, Ma, Xiong, Nan, Yue-min, Ren, Hong, Shen, Tao, Wang, Hao, Wang, Ji-yao, Wang, Tai-ling, Wang, Xiao-jin, Wei, Lai, Xie, Qing, Xie, Wen, Yang, Chang-qing, Yang, Dong-liang, Yu, Yan-yan, Zeng, Min-de, Zhang, Li, Zhao, Xin-yan, Zhuang, Hui
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01.05.2017; Springer Nature B.V
• Subjects: Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - toxicity; Anti-Infective Agents - adverse effects; Anti-Infective Agents - toxicity; Chemical and Drug Induced Liver Injury - epidemiology; Chemical and Drug Induced Liver Injury - pathology; Chemical and Drug Induced Liver Injury - physiopathology; Chemical and Drug Induced Liver Injury - prevention & control; China - epidemiology; Cholestasis - chemically induced; Cholestasis - complications; Cholestasis - pathology; Colorectal Surgery; Diagnosis, Differential; Dietary Supplements - adverse effects; Dietary Supplements - toxicity; Drugs, Chinese Herbal - adverse effects; Female; Guidelines; Guidelines as Topic; Hepatology; Humans; Incidence; Liver; Liver Diseases - epidemiology; Liver Diseases - pathology; Liver Diseases - physiopathology; Liver Diseases - therapy; Male; Medical diagnosis; Medicine; Medicine & Public Health; Prognosis; Risk Factors; Severity of Illness Index; Surgery; Prevention; Recommendations; Pathology; Treatment; Pathogenesis; Clinical type; Drug-induced liver injury; Differential diagnosis; Diagnosis; Epidemiology
• ISSN: 1936-0533; 1936-0541
• DOI: 10.1007/s12072-017-9793-2

Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health products (HP), and dietary supplements (DS). Idiosyncratic DILI is far more common than intrinsic DILI clinically and can be classified into hepatocellular injury, cholestatic injury, hepatocellular-cholestatic mixed injury, and vascular injury based on the types of injured target cells. The CSH guidelines summarized the epidemiology, pathogenesis, pathology, and clinical manifestation and gives 16 evidence-based recommendations on diagnosis, differential diagnosis, treatment, and prevention of DILI.