Impact of a Cancer History on Cardiovascular Events Among Patients With Myocardial Infarction Who Received Revascularization

• Published in: Circulation Journal Vol. 88; no. 2; pp. 207 - 214
• Main Authors: Takeuchi, Taro, Kosugi, Shumpei, Ueda, Yasunori, Ikeoka, Kuniyasu, Yamane, Haruya, Takayasu, Kohtaro, Ohashi, Takuya, Fukushima, Takashi, Horiuchi, Kohei, Iehara, Takashi, Sakamoto, Mai, Ukai, Kazuho, Minami, Shinya, Mizumori, Yuuki, Muraoka, Naoya, Nakamura, Masayuki, Ozaki, Tatsuhisa, Mishima, Tsuyoshi, Abe, Haruhiko, Inoue, Koichi, Matsumura, Yasushi
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 25.01.2024
• Subjects: Aftercare; Cancer history; Cardio-oncology; Coronary Angiography; Humans; Myocardial infarction; Myocardial Infarction - etiology; Myocardial Revascularization - methods; Neoplasms - etiology; Patient Discharge; Percutaneous Coronary Intervention - adverse effects; Retrospective Studies; Revascularization; Risk Factors; Treatment Outcome; Myocardial infarction; Cardio-oncology; Cancer history; Revascularization
• ISSN: 1346-9843; 1347-4820; 1347-4820
• DOI: 10.1253/circj.CJ-22-0838

Background: It remains controversial whether a cancer history increases the risk of cardiovascular (CV) events among patients with myocardial infarction (MI) who undergo revascularization.Methods and Results: Patients who were confirmed as type 1 acute MI (AMI) by coronary angiography were retrospectively analyzed. Patients who died in hospital or those not undergoing revascularization were excluded. Patients with a cancer history were compared with those without it. A cancer history was examined in the in-hospital cancer registry. The primary outcome was a composite of cardiac death, recurrent type 1 MI, post-discharge coronary revascularization, heart failure hospitalization, and stroke. Among 551 AMI patients, 55 had a cancer history (cancer group) and 496 did not (non-cancer group). Cox proportional hazards model revealed that the risk of composite endpoint was significantly higher in the cancer group than in the non-cancer group (adjusted hazard ratio [HR]: 1.78; 95% confidence interval [CI]: 1.13–2.82). Among the cancer group, patients who were diagnosed as AMI within 6 months after the cancer diagnosis had a higher risk of the composite endpoint than those who were diagnosed as AMI 6 months or later after the cancer diagnosis (adjusted HR: 5.43; 95% CI: 1.55–19.07).Conclusions: A cancer history increased the risk of CV events after discharge among AMI patients after revascularization.