Broad collateral damage of drugs against the gut microbiome

• Published in: Nature reviews. Gastroenterology & hepatology Vol. 15; no. 8; pp. 457 - 458
• Main Authors: Spanogiannopoulos, Peter, Turnbaugh, Peter J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2018; Nature Publishing Group
• Subjects: 631/326/2565/2134; 631/326/41/1969/2038; 692/4020/2741/2135; Bacteria; Biomedicine; Digestive system; Gastroenterology; Gastrointestinal Microbiome; Hepatology; Humans; Intestinal microflora; Medicine; Medicine & Public Health; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); News & Views; news-and-views; Toxicity; United States

In a new study, Maier et al. reveal that non-antibiotic drugs intended to target human cells have off-target effects on the growth of human gut bacteria at clinically relevant concentrations. These results emphasize the need for a new field of metagenomic toxicology aimed at a more comprehensive und...