Broad collateral damage of drugs against the gut microbiome

In a new study, Maier et al. reveal that non-antibiotic drugs intended to target human cells have off-target effects on the growth of human gut bacteria at clinically relevant concentrations. These results emphasize the need for a new field of metagenomic toxicology aimed at a more comprehensive und...

Full description

Saved in:
Bibliographic Details
Published inNature reviews. Gastroenterology & hepatology Vol. 15; no. 8; pp. 457 - 458
Main Authors Spanogiannopoulos, Peter, Turnbaugh, Peter J.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.08.2018
Nature Publishing Group
Subjects
631/326/2565/2134
631/326/41/1969/2038
692/4020/2741/2135
Bacteria
Biomedicine
Digestive system
Gastroenterology
Gastrointestinal Microbiome
Hepatology
Humans
Intestinal microflora
Medicine
Medicine & Public Health
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
News & Views
news-and-views
Toxicity
United States
Online AccessGet full text

Cover

More Information
Summary:In a new study, Maier et al. reveal that non-antibiotic drugs intended to target human cells have off-target effects on the growth of human gut bacteria at clinically relevant concentrations. These results emphasize the need for a new field of metagenomic toxicology aimed at a more comprehensive understanding of the toxicity of compounds for humans and their associated microbial communities.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Commentary-3
content type line 23
ISSN:1759-5045
1759-5053
1759-5053
DOI:10.1038/s41575-018-0028-3