Broad collateral damage of drugs against the gut microbiome

In a new study, Maier et al. reveal that non-antibiotic drugs intended to target human cells have off-target effects on the growth of human gut bacteria at clinically relevant concentrations. These results emphasize the need for a new field of metagenomic toxicology aimed at a more comprehensive und...

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Published inNature reviews. Gastroenterology & hepatology Vol. 15; no. 8; pp. 457 - 458
Main Authors Spanogiannopoulos, Peter, Turnbaugh, Peter J.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.08.2018
Nature Publishing Group
Subjects
631/326/2565/2134
631/326/41/1969/2038
692/4020/2741/2135
Bacteria
Biomedicine
Digestive system
Gastroenterology
Gastrointestinal Microbiome
Hepatology
Humans
Intestinal microflora
Medicine
Medicine & Public Health
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
News & Views
news-and-views
Toxicity
United States
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Abstract In a new study, Maier et al. reveal that non-antibiotic drugs intended to target human cells have off-target effects on the growth of human gut bacteria at clinically relevant concentrations. These results emphasize the need for a new field of metagenomic toxicology aimed at a more comprehensive understanding of the toxicity of compounds for humans and their associated microbial communities.
AbstractList In a new study, Maier et al. reveal that non-antibiotic drugs intended to target human cells have off-target effects on the growth of human gut bacteria at clinically relevant concentrations. These results emphasize the need for a new field of metagenomic toxicology aimed at a more comprehensive understanding of the toxicity of compounds for humans and their associated microbial communities.
Audience Academic
Author Spanogiannopoulos, Peter
Turnbaugh, Peter J.
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Cites_doi 10.1038/nrmicro.2016.17
10.1136/gutjnl-2015-310861
10.1016/j.cmet.2014.07.002
10.1038/nm.4345
10.1136/gutjnl-2015-310376
10.1038/nature25979
10.1128/mSystems.00154-17
10.1126/science.aad3503
10.1016/j.cell.2018.02.040
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SubjectTerms 631/326/2565/2134
631/326/41/1969/2038
692/4020/2741/2135
Bacteria
Biomedicine
Digestive system
Gastroenterology
Gastrointestinal Microbiome
Hepatology
Humans
Intestinal microflora
Medicine
Medicine & Public Health
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
News & Views
news-and-views
Toxicity
Title Broad collateral damage of drugs against the gut microbiome
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