Effect of intraoperative goal-directed fluid therapy on the postoperative brain edema in patients undergoing high-grade glioma resections: a study protocol of randomized control trial

Introduction Brain edema is the most frequent postoperative complication after brain tumor resection, especially in patients with high-grade glioma. However, the effect of SVV-based goal-directed fluid therapy (GDFT) on postoperative brain edema and the prognosis remain unclear. Methods and analysis...

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Published inCurrent controlled trials in cardiovascular medicine Vol. 23; no. 1; pp. 950 - 9
Main Authors Liu, Xiaoyuan, Zhang, Xingyue, Fan, Yifang, Li, Shu, Peng, Yuming
Format Journal Article
LanguageEnglish
Published London BioMed Central Ltd 19.11.2022
BioMed Central
BMC
Subjects
Blood pressure
Brain cancer
Brain research
Care and treatment
Causes of
Cerebral edema
Complications and side effects
Development and progression
Dopamine
Edema
Evaluation
Fluid therapy
Glioma
Gliomas
Hospitals
Length of stay
Morbidity
Mortality
Patient outcomes
Study Protocol
Surgery
Tumors
China
Beijing China
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Summary:Introduction Brain edema is the most frequent postoperative complication after brain tumor resection, especially in patients with high-grade glioma. However, the effect of SVV-based goal-directed fluid therapy (GDFT) on postoperative brain edema and the prognosis remain unclear. Methods and analysis This is a prospective, randomized, double-blinded, parallel-controlled trial aiming to observe whether stroke volume variation (SVV)-based GDFT could improve the postoperative brain edema in patients undergoing supratentorial high-grade gliomas compared with traditional fluid therapy. The patient will be given 3 ml/kg hydroxyethyl starch solution when the SVV is greater than 15% continuously for more than 5 min intraoperatively. The primary outcome will be postoperative cerebral edema volume on brain CT within 24 h. Ethics and dissemination This trial has been registered at ClinicalTrials.gov (NCT03323580) and approved by the Ethics Committee of Beijing Tiantan Hospital, Capital Medical University (reference number: KY2017-067-02). The findings will be disseminated in peer-reviewed journals and presented at national or international conferences relevant to the subject fields. Trial registration ClinicalTrials.gov NCT03323580 (First posted: October 27, 2017; Last update posted: February 11, 2022).
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ISSN:1745-6215
1745-6215
DOI:10.1186/s13063-022-06859-9