Nootropic Effects of Filipendula Vulgaris Moench Water Extract Fractions

• Published in: Bulletin of experimental biology and medicine Vol. 159; no. 3; pp. 376 - 379
• Main Authors: Shilova, I. V., Suslov, N. I., Amelchenko, V. P.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2015; Springer; Springer Nature B.V
• Subjects: Animals; Biological products; Biomedical and Life Sciences; Biomedicine; Cell Biology; Central nervous system agents; Exploratory Behavior - drug effects; Filipendula - chemistry; Internal Medicine; Laboratory Medicine; Male; Mice; Nootropic Agents - chemistry; Nootropic Agents - pharmacology; Pathology; Plant Components, Aerial - chemistry; Plant Extracts - chemistry; Water - chemistry; conditioned passive avoidance response
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-015-2967-9

Nootropic activity of water extract fractions from aerial parts of Filipendula vulgaris Moench was demonstrated on the models of hermetic volume hypoxia, conditioned passive avoidance response, open field test, and forced swimming with a load. The fractions stimulated hypoxic resistance, normalized orientation and exploratory behavior, improved conditioned response reproduction during testing after hypoxic injury, and increased exercise tolerance. Fractionation of the extract led to dissociation of the effect components, which suggests that individual constituents have specifi c characteristics. Ethylacetate fraction exhibited most pronounced nootropic activity and was superior to plant extract by some characteristics. The detected effects seemed to be caused by modulation of the hippocampus activity the under the effects of phenol and triterpene compounds.