Electrophysiological Proxy of Cognitive Reserve Index

• Published in: Frontiers in human neuroscience Vol. 15; p. 690856
• Main Authors: Khachatryan, Elvira, Wittevrongel, Benjamin, Perovnik, Matej, Tournoy, Jos, Schoenmakers, Birgitte, Van Hulle, Marc M.
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 08.07.2021; Frontiers Media S.A
• Subjects: aging; Brain damage; Brain mapping; Cognitive ability; cognitive reserve; Education; EEG; Electroencephalography; Event-related potentials; Executive function; Functional magnetic resonance imaging; Human Neuroscience; Medical imaging; Memory; Neuroimaging; oddball paradigm; Older people; P300 - event related potential; Questionnaires; Short term memory
• ISSN: 1662-5161; 1662-5161
• DOI: 10.3389/fnhum.2021.690856

Cognitive reserve (CR) postulates that individual differences in task performance can be attributed to differences in the brain’s ability to recruit additional networks or adopt alternative cognitive strategies. Variables that are descriptive of lifetime experience such as socioeconomic status, educational attainment, and leisure activity are common proxies of CR. CR is mostly studied using neuroimaging techniques such as functional MRI (fMRI) in which case individuals with a higher CR were observed to activate a smaller brain network compared to individuals with a lower CR, when performing a task equally effectively (higher efficiency), and electroencephalography (EEG) where a particular EEG component (P300) that reflects the attention and working memory load, has been targeted. Despite the contribution of multiple factors such as age, education (formal and informal), working, leisure, and household activities in CR formation, most neuroimaging studies, and those using EEG in particular, focus on formal education level only. The aim of the current EEG study is to investigate how the P300 component, evoked in response to an oddball paradigm, is associated with other components of CR besides education, such as working and leisure activity in older adults. We have used hereto a recently introduced CR index questionnaire (CRIq) that quantifies both professional and leisure activities in terms of their cognitive demand and number of years practiced, as well as a data-driven approach for EEG analysis. We observed complex relationships between CRIq subcomponents and P300 characteristics. These results are especially important given that, unlike previous studies, our measurements (P300 and CRIq) do not require active use of the same executive function and, thus, render our results free of a collinearity bias.