The Elevated Expression of a Mismatch Repair Protein Is a Predictor for Biochemical Recurrence After Radical Prostatectomy
Purpose: The inability to predict clinical outcome of prostate cancer is a major impediment to effective treatment decisions and patient counseling. New markers of recurrence are needed to improve the accuracy of risk assessment and treatment of prostate cancer. Our previous studies identified a mis...
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Published in | Cancer epidemiology, biomarkers & prevention Vol. 18; no. 1; pp. 57 - 64 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Philadelphia, PA
American Association for Cancer Research
01.01.2009
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Subjects | |
Online Access | Get full text |
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Summary: | Purpose: The inability to predict clinical outcome of prostate cancer is a major impediment to effective treatment decisions
and patient counseling. New markers of recurrence are needed to improve the accuracy of risk assessment and treatment of prostate
cancer. Our previous studies identified a mismatch repair protein, PMS2, to be elevated in prostate cancer; here, we investigate
the prognostic potential of this marker. We hypothesized that the elevation of PMS2 would correlate with disease outcome.
Experimental Design: Retrospective quantitative immunohistochemistry was done to measure PMS2 in high-grade cancers of 166
men treated by radical prostatectomy with a biochemical recurrence rate of 56%. Associations between PMS2 levels, pathologic
variables, and biochemical recurrence over time were determined.
Results: The mean level of PMS2 protein was consistently higher in both cancer-associated benign epithelium and cancer cells
of patients who recurred, compared with nonrecurrent patients. PMS2 was an independent predictor of time-to-recurrence in
Cox multivariate analyses and significantly stratified patients based on outcome. PMS2 was able to improve the sensitivity
of total percent Gleason 4/5 as a risk factor for recurrence in this cohort.
Conclusions: PMS2 protein levels were shown to be a predictor of time-to-recurrence after surgery. This study is the first
to document that the elevation of a mismatch repair protein negatively correlates with prognosis and has implications in patient
diagnosis and molecular profiling. (Cancer Epidemiol Biomarkers Prev 2009;18(1):57–64) |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1055-9965 1538-7755 |
DOI: | 10.1158/1055-9965.EPI-08-0377 |