Spectral hallmark of auditory-tactile interactions in the mouse somatosensory cortex

• Published in: Communications biology Vol. 3; no. 1; p. 64
• Main Authors: Zhang, Manning, Kwon, Sung Eun, Ben-Johny, Manu, O’Connor, Daniel H., Issa, John B.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.02.2020; Nature Publishing Group
• Subjects: 14/35; 14/69; 631/1647/328/2057; 631/378/2619/2618; 631/378/2620/2618; 64/110; Animals; Auditory Perception - physiology; Biology; Biomedical and Life Sciences; Calcium - metabolism; Calcium imaging; Evoked Potentials; Hearing; Life Sciences; Mice; Molecular Imaging - methods; Motor Activity; Neuroimaging; Neurons - physiology; Physical Stimulation; Psychomotor Performance; Sensory integration; Somatosensory cortex; Somatosensory Cortex - physiology; Tactile stimuli; Touch - physiology
• ISSN: 2399-3642; 2399-3642
• DOI: 10.1038/s42003-020-0788-5

To synthesize a coherent representation of the external world, the brain must integrate inputs across different types of stimuli. Yet the mechanistic basis of this computation at the level of neuronal populations remains obscure. Here, we investigate tactile-auditory integration using two-photon Ca 2+ imaging in the mouse primary (S1) and secondary (S2) somatosensory cortices. Pairing sound with whisker stimulation modulates tactile responses in both S1 and S2, with the most prominent modulation being robust inhibition in S2. The degree of inhibition depends on tactile stimulation frequency, with lower frequency responses the most severely attenuated. Alongside these neurons, we identify sound-selective neurons in S2 whose responses are inhibited by high tactile frequencies. These results are consistent with a hypothesized local mutually-inhibitory S2 circuit that spectrally selects tactile versus auditory inputs. Our findings enrich mechanistic understanding of multisensory integration and suggest a key role for S2 in combining auditory and tactile information. Manning Zhang et al. investigate how the mouse brain makes sense of multiple sensory types, such as sound and touch using two-photon Ca 2+ imaging in the somatosensory cortex while exposing the mouse to sound and whisker simulation. They identify a potential mutually-inhibitory circuit between sound and touch that depends on the relative frequencies of the different stimuli.