Association of PS gene polymorphism and soluble P-selectin levels in atrial fibrillation thromboembolism population in Xinjiang

• Published in: Biochemical and biophysical research communications Vol. 452; no. 3; pp. 303 - 307
• Main Authors: Bai, Ling, Liu, Zhiqiang, Bakeyi, Maerjiaen, Lu, Wuhong, He, Pengyi, Yang, Yuchun, Wulasihan, Muhuyati
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.09.2014
• Subjects: Adult; Aged; Aged, 80 and over; Alleles; Atrial Fibrillation - complications; Atrial Fibrillation - ethnology; Atrial Fibrillation - genetics; Atrial Fibrillation - pathology; Atrial fibrillation thromboembolism; Axons; Base Sequence; China; Ethnic Groups; Female; Gene Expression; Gene Frequency; Gene polymorphism; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Molecular Sequence Data; P-Selectin - blood; P-Selectin - genetics; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Soluble P-selectin; Thromboembolism - complications; Thromboembolism - ethnology; Thromboembolism - genetics; Thromboembolism - pathology; China; Atrial fibrillation thromboembolism; Soluble P-selectin; Gene polymorphism
• ISSN: 0006-291X; 1090-2104
• DOI: 10.1016/j.bbrc.2014.07.120

•Atrial fibrillation is the most common clinical arrhythmia, it can lead to thromboembolism.•Ps gene polymorphism and sPs plasma levels are associated with thrombosis.•We analysis the association of Ps gene polymorphism and sPs levels in atrial fibrillation thromboembolism population.•We study whether there are ethnic differences between Xinjiang Uigur and Han population in PS genes. To investigate the association between the polymorphism of P choose element (p. selectin, PS) and soluble P-selectin levels in atrial fibrillation (AF) thromboembolism in Han and Uigur population of Xinjiang. Method: Using ELISA method determination of plasma level of sPs. The frequency distributions of SNP sP-selectin gene promoter (−2123C/G) and SNP in exon region (Thr715Pro) were investigated by polymerase chain reaction (PCR)-restriction fragment length polymorphism and direct DNA sequence analysis among 302 Xinjiang Uigur and 340 age- and sex-matched Han people. Results: Cases sPs exist significant difference serum level and the control group. The frequencies of the −2123C/G allele among the Uigur population had no significant differences from those of the Han population. Thr715Pro did not show any polymorphism in the two populations. Conclusions: The sP-selectin gene polymorphisms are associated with serum sP-selectin levels or thromboembolic events, suggesting that the patients with nonvalvular AF and thromboembolic events may have genetic susceptibility.