The Emerging Role of Neural Cell-Derived Exosomes in Intercellular Communication in Health and Neurodegenerative Diseases

Intercellular communication in the central nervous system (CNS) is essential for brain growth, development, and homeostasis maintenance and, when dysfunctional, is involved in the occurrence and development of neurodegenerative diseases. Increasing evidence indicates that extracellular vesicles, esp...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in neuroscience Vol. 15; p. 738442
Main Authors Huo, Luyao, Du, Xinzhe, Li, Xinrong, Liu, Sha, Xu, Yong
Format Journal Article
LanguageEnglish
Published Lausanne Frontiers Research Foundation 31.08.2021
Frontiers Media S.A
Subjects
Biosynthesis
Cell adhesion & migration
Cell interactions
Central nervous system
Communication
Exosomes
Extracellular matrix
extracellular vesicles
glial cells
health
Homeostasis
Inflammation
intercellular communication
Lipids
Metabolism
Metabolites
Nervous system
Neurodegenerative diseases
Neurons
Neuroscience
Physiology
Proteins
Regeneration
Signal transduction
Synaptic plasticity
Waste disposal
Online AccessGet full text

Cover

More Information
Summary:Intercellular communication in the central nervous system (CNS) is essential for brain growth, development, and homeostasis maintenance and, when dysfunctional, is involved in the occurrence and development of neurodegenerative diseases. Increasing evidence indicates that extracellular vesicles, especially exosomes, are critical mediators of intercellular signal transduction. Under physiological and pathological conditions, neural cells secret exosomes with the influence of many factors. These exosomes can carry specific proteins, lipids, nucleic acids, and other bioactive substances to the recipient cells to regulate their function. Depending on the CNS environment, as well as the origin and physiological or pathological status of parental cells, exosomes can mediate a variety of different effects, including synaptic plasticity, nutritional metabolic support, nerve regeneration, inflammatory response, anti-stress effect, cellular waste disposal, and the propagation of toxic components, playing an important role in health and neurodegenerative diseases. This review will discuss the possible roles of exosomes in CNS intercellular communication in both physiologic and neurodegenerative conditions.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Edited by: Peng Lei, Sichuan University, China
This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience
Reviewed by: Mukesh Gautam, Northwestern University, United States; Ye Xiong, Henry Ford Health System, United States
These authors have contributed equally to this work
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2021.738442