p66ShcA promotes malignant breast cancer phenotypes by alleviating energetic and oxidative stress

• Published in: Redox biology Vol. 70; p. 103028
• Main Authors: Lewis, Kyle, La Selva, Rachel, Maldonado, Elias, Annis, Matthew G., Najyb, Ouafa, Cepeda Cañedo, Eduardo, Totten, Stephanie, Hébert, Steven, Sabourin, Valérie, Mirabelli, Caitlynn, Ciccolini, Emma, Lehuédé, Camille, Choinière, Luc, Russo, Mariana, Avizonis, Daina, Park, Morag, St-Pierre, Julie, Kleinman, Claudia L., Siegel, Peter M., Ursini-Siegel, Josie
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2024; Elsevier
• Subjects: Anoikis; Breast cancer; Breast Neoplasms - metabolism; Cell Line, Tumor; Female; Glutathione; Humans; Metabolic plasticity; Oxidative stress; Oxidative Stress - physiology; p66ShcA; Phenotype; Shc Signaling Adaptor Proteins - genetics; Shc Signaling Adaptor Proteins - metabolism; Src Homology 2 Domain-Containing, Transforming Protein 1 - metabolism; Tumor Microenvironment; Oxidative stress; Anoikis; Breast cancer; p66ShcA; Metabolic plasticity; Glutathione

Significant efforts have focused on identifying targetable genetic drivers that support the growth of solid tumors and/or increase metastatic ability. During tumor development and progression to metastatic disease, physiological and pharmacological selective pressures influence parallel adaptive str...