Role of galanin and galanin(1–15) on central cardiovascular control
Galanin and the N-terminal fragment Galanin(1–15) are involved in central cardiovascular regulation. The present paper reviews the recent cardiovascular results obtained by intracisternal injections of Galanin and Galanin(1–15) showing that: (A) the Galanin antagonist M40 blocks the central cardiova...
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Published in | Neuropeptides (Edinburgh) Vol. 39; no. 3; pp. 185 - 190 |
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Main Authors | , , , , , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
Oxford
Elsevier Ltd
01.06.2005
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Galanin and the N-terminal fragment Galanin(1–15) are involved in central cardiovascular regulation. The present paper reviews the recent cardiovascular results obtained by intracisternal injections of Galanin and Galanin(1–15) showing that: (A) the Galanin antagonist M40 blocks the central cardiovascular responses induced by Galanin(1–15) but not those elicited by Galanin; (B) both Galanin and Galanin(1–15) induce the expression of c-Fos in cardiovascular nuclei of the medulla oblongata with different temporal and spatial profiles; (C) the cardiovascular action of Galanin(1–15), but not Galanin, is mediated by peripheral β-receptor stimulation; (D) and it is demonstrated an antagonistic Galanin/α2-adrenoceptors interaction as well as a differential modulation of central cardiovascular responses of Angiotensin II by Galanin or Galanin(1–15). All these data strengthen the involvement of both Galanin molecules as neuromodulators on central cardiovascular regulation. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0143-4179 1532-2785 |
DOI: | 10.1016/j.npep.2004.12.009 |