Role of galanin and galanin(1–15) on central cardiovascular control

• Published in: Neuropeptides (Edinburgh) Vol. 39; no. 3; pp. 185 - 190
• Main Authors: Díaz-Cabiale, Z., Parrado, C., Vela, C., Razani, H., Coveñas, R., Fuxe, K., Narváez, J.A.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Oxford Elsevier Ltd 01.06.2005; Elsevier
• Subjects: Animals; Biological and medical sciences; Brain Stem - drug effects; Brainstem; Cardiovascular control; Cardiovascular System - drug effects; Fundamental and applied biological sciences. Psychology; Galanin; Galanin - pharmacology; Galanin - physiology; Galanin receptor; Galanin(1–15); M40; Medicin och hälsovetenskap; Peptide Fragments - pharmacology; Peptide Fragments - physiology; Vertebrates: endocrinology; Galanin(1–15); M40; Cardiovascular control; Galanin; Galanin receptor; Brainstem; Brain stem; Central nervous system; Galanin(1-15); Neuropeptide; Encephalon
• ISSN: 0143-4179; 1532-2785
• DOI: 10.1016/j.npep.2004.12.009

Galanin and the N-terminal fragment Galanin(1–15) are involved in central cardiovascular regulation. The present paper reviews the recent cardiovascular results obtained by intracisternal injections of Galanin and Galanin(1–15) showing that: (A) the Galanin antagonist M40 blocks the central cardiovascular responses induced by Galanin(1–15) but not those elicited by Galanin; (B) both Galanin and Galanin(1–15) induce the expression of c-Fos in cardiovascular nuclei of the medulla oblongata with different temporal and spatial profiles; (C) the cardiovascular action of Galanin(1–15), but not Galanin, is mediated by peripheral β-receptor stimulation; (D) and it is demonstrated an antagonistic Galanin/α2-adrenoceptors interaction as well as a differential modulation of central cardiovascular responses of Angiotensin II by Galanin or Galanin(1–15). All these data strengthen the involvement of both Galanin molecules as neuromodulators on central cardiovascular regulation.