Role of galanin and galanin(1–15) on central cardiovascular control

Galanin and the N-terminal fragment Galanin(1–15) are involved in central cardiovascular regulation. The present paper reviews the recent cardiovascular results obtained by intracisternal injections of Galanin and Galanin(1–15) showing that: (A) the Galanin antagonist M40 blocks the central cardiova...

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Published inNeuropeptides (Edinburgh) Vol. 39; no. 3; pp. 185 - 190
Main Authors Díaz-Cabiale, Z., Parrado, C., Vela, C., Razani, H., Coveñas, R., Fuxe, K., Narváez, J.A.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Oxford Elsevier Ltd 01.06.2005
Elsevier
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Summary:Galanin and the N-terminal fragment Galanin(1–15) are involved in central cardiovascular regulation. The present paper reviews the recent cardiovascular results obtained by intracisternal injections of Galanin and Galanin(1–15) showing that: (A) the Galanin antagonist M40 blocks the central cardiovascular responses induced by Galanin(1–15) but not those elicited by Galanin; (B) both Galanin and Galanin(1–15) induce the expression of c-Fos in cardiovascular nuclei of the medulla oblongata with different temporal and spatial profiles; (C) the cardiovascular action of Galanin(1–15), but not Galanin, is mediated by peripheral β-receptor stimulation; (D) and it is demonstrated an antagonistic Galanin/α2-adrenoceptors interaction as well as a differential modulation of central cardiovascular responses of Angiotensin II by Galanin or Galanin(1–15). All these data strengthen the involvement of both Galanin molecules as neuromodulators on central cardiovascular regulation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0143-4179
1532-2785
DOI:10.1016/j.npep.2004.12.009