Distributed context-dependent choice information in mouse posterior cortex

• Published in: Nature communications Vol. 14; no. 1; p. 192
• Main Authors: Orlandi, Javier G., Abdolrahmani, Mohammad, Aoki, Ryo, Lyamzin, Dmitry R., Benucci, Andrea
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.01.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 14/35; 14/63; 49/56; 631/378/116/1925; 631/378/2613; 631/378/2649; 631/378/3920; 64/60; Animal cognition; Animals; Brain; Cerebral Cortex; Choice Behavior; Cognitive ability; Computational neuroscience; Context; Decision Making; Embedding; Humanities and Social Sciences; Mice; multidisciplinary; Neural networks; Neural Networks, Computer; Recurrent neural networks; Science; Science (multidisciplinary); Somatosensory cortex; Visual signals; Visual tasks
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-023-35824-6

Choice information appears in multi-area brain networks mixed with sensory, motor, and cognitive variables. In the posterior cortex—traditionally implicated in decision computations—the presence, strength, and area specificity of choice signals are highly variable, limiting a cohesive understanding of their computational significance. Examining the mesoscale activity in the mouse posterior cortex during a visual task, we found that choice signals defined a decision variable in a low-dimensional embedding space with a prominent contribution along the ventral visual stream. Their subspace was near-orthogonal to concurrently represented sensory and motor-related activations, with modulations by task difficulty and by the animals’ attention state. A recurrent neural network trained with animals’ choices revealed an equivalent decision variable whose context-dependent dynamics agreed with that of the neural data. Our results demonstrated an independent, multi-area decision variable in the posterior cortex, controlled by task features and cognitive demands, possibly linked to contextual inference computations in dynamic animal–environment interactions. In the posterior cortex, which is involved in decision making, the strength and area specificity of choice signals are highly variable. Here the authors show that the representation of choice in the posterior area of the mouse brain is orthogonal to that of sensory and movement-related signals, with modulations determined by task features and cognitive demands.