Chinese Herbal Medicine for Treating Epilepsy

• Published in: Frontiers in neuroscience Vol. 15; p. 682821
• Main Authors: Lin, Chia-Hui, Hsieh, Ching-Liang
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 02.07.2021; Frontiers Media S.A
• Subjects: Alcohol; antiepileptic effect; Apoptosis; Cannabidiol; Chinese herbal medicine; Clinical trials; complementary therapy; Convulsions & seizures; diet therapy; Disease; Drugs; Epilepsy; epileptic seizure; FDA approval; Glutamic acid receptors (ionotropic); Herbal medicine; Herbs; Inflammation; Lipid peroxidation; Low income groups; Marijuana; Medicinal plants; Mutation; N-Methyl-D-aspartic acid receptors; Neuroprotection; Neuroscience; Oxidative stress; Pathogenesis; Potassium; Proteins; Seizures; Surgery; Traditional Chinese medicine; γ-Aminobutyric acid; Taiwan
• ISSN: 1662-453X; 1662-4548; 1662-453X
• DOI: 10.3389/fnins.2021.682821

Chinese herbal medicine has a long history of use for treating epilepsy. Because of the side effects of Western antiepileptic therapy and the quest for more accessible treatment, complementary and alternative medicines have become popular. Traditional Chinese medical diet therapy appears to be safe and effective. We searched PubMed and the Cochrane Library through November 2020 for the use of traditional Chinese medicine in clinical settings, including plants, fungi, and animals. Combinations of keywords included “epilepsy,” “seizure,” “antiepileptic,” “anticonvulsive,” “Chinese herbal medicine,” “Chinese herb,” and each of the Latin names, English names, and scientific names of herbs. We also summarized the sources and functions of these herbs in Chinese medicine. Different herbs can be combined to increase antiepileptic effects through various mechanisms, including anti-inflammation, antioxidation, GABAergic effect enhancement, modulation of NMDA channels and sodium channel, and neuroprotection. Despite reports of their anticonvulsive effects, adequate experimental evidence and randomized controlled clinical trials are required to confirm their antiepileptic effects.