Primary encephalic plasma cell tumor in a dog

• Published in: Veterinary pathology Vol. 34; no. 6; pp. 621 - 627
• Main Authors: Sheppard, B.J, Chrisman, C.L, Newell, S.M, Raskin, R.E, Homer, B.L
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.11.1997
• Subjects: Animals; BRAIN; Brain Neoplasms - diagnosis; Brain Neoplasms - pathology; Brain Neoplasms - veterinary; Brain Stem - pathology; CASE STUDIES; CELLS; CELLULE; CELULAS; CEREBRO; CEREBROSPINAL FLUID; CHIEN; CLINICAL ASPECTS; DIAGNOSIS; DIAGNOSTIC; DIAGNOSTICO; Dog Diseases - diagnosis; Dog Diseases - metabolism; Dog Diseases - pathology; DOGS; ENCEPHALE; ENDOPLASMIC RETICULUM; Endoplasmic Reticulum, Rough - ultrastructure; ESTUDIOS DE CASOS PRACTICOS; ETUDE DE CAS; Female; FLUIDO CEREBROESPINAL; Golgi Apparatus - ultrastructure; HISTOPATHOLOGIE; HISTOPATHOLOGY; HISTOPATOLOGIA; Immunoglobulin A - analysis; Immunoglobulin A - metabolism; IMMUNOLOGIE; IMMUNOLOGY; INMUNOLOGIA; INSPECCION POSTMORTEM; LESION; LESIONES; LESIONS; LIQUIDE CEPHALORACHIDIEN; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - veterinary; Microscopy, Electron - methods; Microscopy, Electron - veterinary; NECROPSIE; NEOPLASMAS; NEOPLASME; NEOPLASMS; PERRO; Plasmacytoma - chemistry; Plasmacytoma - diagnosis; Plasmacytoma - veterinary; POSTMORTEM EXAMINATION; RETICULO ENDOPLASMATICO; RETICULUM ENDOPLASMIQUE; SEROLOGY; encephalic; intracranial; pathology; plasma cell tumor; Canine
• ISSN: 0300-9858; 1544-2217
• DOI: 10.1177/030098589703400612

A 5-year-old female spayed Spitz dog had a 5-week history of right head tilt, seizures, and progressive quadriplegia. Analysis of cerebrospinal fluid revealed 27,600 white blood cells per microliter with 63% mononuclear phagocytes, 27% lymphocytes, 6% neutrophils, 3% plasmacytoid cells, and 1% eosinophils, and over 2000 mg/dl protein. On contrast-enhanced magnetic resonance images, a focal 1-cm oval lesion was identified in the right ventral brainstem. There was also marked contrast enhancement of the meninges in the following areas: surrounding the brainstem, outlining cerebellar folia, along the ventral floor of the brain and extending to the falx cerebri, and partially outlining the left frontal lobe. At necropsy, the areas of contrast enhancement corresponded to the presence of compact cellular sheets of pleomorphic, anisocytotic, oval to polygonal neoplastic cells with plasmacytoid differentiation. The smaller of these plasmacytoid cells stained predominantly for cytoplasmic immunoglobulin A using immunoperoxidase methodology. Ultrastructurally, the neoplastic cells had morphologic features typical of plasma cells, with large amounts of predominantly rough endoplasmic reticulum with variably prominent Golgi formation. This is the first report of a canine primary intracranial malignant plasma cell tumor.