Biochemical mechanisms implemented by human acute myeloid leukemia cells to suppress host immune surveillance

Acute myeloid leukaemia (AML) is a blood/bone marrow cancer originating from myeloid cell precusors capable of self-renewing. AML cells implement biochemical mechanisms which allow them not only to survive, but also to successfully escape immune surveillance. ln this work, we discuss crucial molecul...

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Published inCellular & molecular immunology Vol. 15; no. 11; pp. 989 - 991
Main Authors Yasinska, Inna M., Gonçalves Silva, Isabel, Sakhnevych, Svetlana, Gibbs, Bernhard F., Raap, Ulrike, Fasler-Kan, Elizaveta, Sumbayev, Vadim V.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.11.2018
Nature Publishing Group
Subjects
Acute myeloid leukemia
Antibodies
Biomedical and Life Sciences
Biomedicine
Bone cancer
Bone marrow
Cancer
Correspondence
Immunology
Immunosurveillance
Leukemia
Medical Microbiology
Microbiology
Molecular modelling
Myeloid leukemia
Vaccine
Acute myeloid leukaemia
Immune surveillance
galectin-9
Tim-3
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Summary:Acute myeloid leukaemia (AML) is a blood/bone marrow cancer originating from myeloid cell precusors capable of self-renewing. AML cells implement biochemical mechanisms which allow them not only to survive, but also to successfully escape immune surveillance. ln this work, we discuss crucial molecular mechanisms used by human AML cells in order to evade immune attack.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
content type line 23
ObjectType-Review-2
ISSN:1672-7681
2042-0226
DOI:10.1038/s41423-018-0047-6