Relationship between CETP gene polymorphisms with coronary artery disease in Polish population

• Published in: Molecular biology reports Vol. 45; no. 6; pp. 1929 - 1935
• Main Authors: Iwanicka, Joanna, Iwanicki, Tomasz, Niemiec, Paweł, Balcerzyk, Anna, Krauze, Jolanta, Górczyńska-Kosiorz, Sylwia, Ochalska-Tyka, Anna, Grzeszczak, Władysław, Żak, Iwona
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.12.2018; Springer Nature B.V
• Subjects: Aged; Alleles; Animal Anatomy; Animal Biochemistry; Asian Continental Ancestry Group - genetics; Biomedical and Life Sciences; Cardiovascular disease; Case-Control Studies; CETP gene; Cholesterol; Cholesterol Ester Transfer Proteins - blood; Cholesterol Ester Transfer Proteins - genetics; Cholesterol, HDL - blood; Cholesterol, HDL - genetics; Cholesteryl ester transfer protein; Coronary artery; Coronary Artery Disease - genetics; Coronary vessels; Female; Gene Frequency - genetics; Gene polymorphism; Genetic Predisposition to Disease - genetics; Genotype; Heart diseases; Histology; Homozygotes; Humans; Hydrophobicity; Life Sciences; Linkage Disequilibrium - genetics; Male; Middle Aged; Morphology; Original; Original Article; Poland - epidemiology; Polymorphism; Polymorphism, Single Nucleotide - genetics; Risk Factors; Single-nucleotide polymorphism; Poland; SNPs; CETP; Lipids; Coronary artery disease; Linkage disequilibrium
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-018-4342-1

The cholesteryl ester transfer protein (CETP) gene encodes a hydrophobic glycoprotein that plays a crucial role in the reverse transport of cholesterol. The aim of the present study was to determine whether CETP polymorphisms (rs1532624, rs247616 and rs708272) are associated with coronary artery disease (CAD) in a Polish population. Serum lipid levels and single nucleotide polymorphisms of CETP genes were determined in 494 subjects: 248 patients with premature CAD and 246 blood donors as controls. Selected polymorphisms were examined using TaqMan PCR analysis. We found that CAD risk was significantly higher for CC homozygotes and C allele carriers of the rs247616 polymorphism than for carriers with the T allele (OR 1.89, 95% CI 1.29–2.76, p = 0.001 and OR 1.51, 95% CI 1.14–1.99, p = 0.003) and likewise for the CC genotype of the rs1532624 polymorphism than for those with the A allele (OR 1.59, 95% CI 1.05–2.40, p = 0.026). Moreover, T allele carriers of the rs708272 polymorphism had significantly higher total cholesterol levels compared to CC homozygotes (p < 0.05) in the healthy controls. We also observed an allelic pattern, C (rs2477616) C (rs708272) C (rs1532624), which increased susceptibility to CAD by 43% (OR = 1.43, 95% CI 1.10–1.85, p = 0.006). In conclusion, the rs247616 and rs1532624 polymorphisms of CETP may modulate the risk of CAD in Polish population.