Circulating nucleic acids in plasma and serum: diagnosis and prognosis in cancer

The presence of DNA and RNA circulating in human plasma and serum is described. The known sources of the DNA/RNA in blood, the ability of these nucleic acids to enter other cells and to express in the recipient cells are considered along with their relationship to metastases. The possible role(s) of...

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Bibliographic Details
Published inThe EPMA journal Vol. 1; no. 3; pp. 503 - 512
Main Author Gahan, Peter Brian
Format Journal Article
LanguageEnglish
Published London BioMed Central 01.09.2010
Springer Nature B.V
Springer Netherlands
Subjects
Biomedical and Life Sciences
Biomedicine
Deoxyribonucleic acid
DNA
Medicine/Public Health
Review
Review Article
Circulating DNA/RNA
Diagnosis
Personalized medicine
Plasma/serum
Cancer
Nucleic acid uptake/expression
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Summary:The presence of DNA and RNA circulating in human plasma and serum is described. The known sources of the DNA/RNA in blood, the ability of these nucleic acids to enter other cells and to express in the recipient cells are considered along with their relationship to metastases. The possible role(s) of the DNA/RNA in personalized clinical diagnosis, monitoring of treatment and prognosis in oncology are discussed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1878-5077
1878-5085
DOI:10.1007/s13167-010-0021-6