The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire for patients with Bone Metastases: The EORTC QLQ-BM22

• Published in: European Journal of Cancer Vol. 45; no. 7; pp. 1146 - 1152
• Main Authors: Chow, Edward, Hird, Amanda, Velikova, Galina, Johnson, Colin, Dewolf, Linda, Bezjak, Andrea, Wu, Jackson, Shafiq, Jesmin, Sezer, Orhan, Kardamakis, Dimitrios, Linden, Yvette van der, Ma, Brigette, Castro, Monica, Arnalot, Palmira Foro, Ahmedzai, Sam, Clemons, Mark, Hoskin, Peter, Yee, Albert, Brundage, Michael, Bottomley, Andrew
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.05.2009; Elsevier
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Bone metastases; Bone Neoplasms - psychology; Bone Neoplasms - secondary; Cancer; EORTC; Europe; Female; Guidelines as Topic; Health Status Indicators; Health-related quality of life; Hematology, Oncology and Palliative Medicine; Humans; Interviews as Topic; Male; Medical sciences; Middle Aged; Neoplasms - psychology; Pain symptoms; Patient Participation; Pharmacology. Drug treatments; Psychometrics; Quality of Life; Questionnaire; Surveys and Questionnaires - standards; Tumors; Europe; Health-related quality of life; Pain symptoms; Questionnaire; EORTC; Bone metastases; Cancer; Human; Diseases of the osteoarticular system; Research; Malignant tumor; Health-Related Quality of Life; Quality of life; Symptomatology; Bone metastasis; Cancerology; Pain; Treatment; European Organization for Research and Treatment of Cancer
• ISSN: 0959-8049; 1879-0852; 1359-6349
• DOI: 10.1016/j.ejca.2008.11.013

Abstract Aim The aim of this study was to develop a bone metastases module to supplement the European Organisation for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30) or the EORTC QLQ-C15-PAL for patients with bone metastases. Methods Phases 1–2 of module development were conducted in Canada, Australia and Germany according to EORTC QOL group guidelines. Phase 3 was conducted in nine countries in seven languages. Results Sixty-one health-related quality of life (HRQOL) issues were generated from health care professionals ( n = 152) and patients ( n = 413). This resulted in a 22-item provisional module. Further testing in 170 patients from nine countries resulted in the EORTC QLQ-BM22 module, containing 22 items, conceptualised into both symptom scales, with five painful sites and three pain characteristics, and also functional scales, with eight functional interference and six psychosocial aspects. Conclusion This study provides a provisional comprehensive HRQOL measurement tool for future trials, which will continue to undergo further validation.