Epidemiological description and trajectories of patients with prostate cancer in Denmark: an observational study of 7448 patients

• Published in: BMC research notes Vol. 16; no. 1; pp. 1 - 341
• Main Authors: Blanes-Vidal, Victoria, Tashk, Ashkan, Cantuaria, Manuella Lech, Hansen, Rasmus Sagaard, Poulsen, Charlotte A, Poulsen, Mads H, Krogh, Marie-Louise, Sheikh, Saren P, Nadimi, Esmaeil S
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 16.11.2023; BioMed Central; BMC
• Subjects: Artificial intelligence; Biomarkers; Biopsy; Cancer; Cancer patients; Clinical data; Clinical medicine; Codes; Datasets; Diagnosis; Disease; Electronic health records; Epidemiology; Health aspects; Metastases; Metastasis; Mortality; Oncology, Experimental; Patients; Population; Prostate cancer; Survival; Trajectory; Tumors; Ultrasonic imaging; Variance analysis; Denmark
• ISSN: 1756-0500; 1756-0500
• DOI: 10.1186/s13104-023-06599-2

Identification of patients at high risk of aggressive prostate cancer is a major clinical challenge. With the view of developing artificial intelligence-based methods for identification of these patients, we are constructing a comprehensive clinical database including 7448 prostate cancer (PCa) Danish patients. In this paper we provide an epidemiological description and patients' trajectories of this retrospective observational population, to contribute to the understanding of the characteristics and pathways of PCa patients in Denmark. Individuals receiving a PCa diagnosis during 2008-2014 in Region Southern Denmark were identified, and all diagnoses, operations, investigations, and biochemistry analyses, from 4 years prior, to 5 years after PCa diagnosis were obtained. About 85.1% were not diagnosed with metastatic PCa during the study period (unaggressive PCa); 9.2% were simultaneously diagnosed with PCa and metastasis (aggressive-advanced PCa), while 5.7% were not diagnosed with metastatic PCa at first, but they were diagnosed with metastasis at some point during the 5 years follow-up (aggressive-not advanced PCa). Patients with unaggressive PCa had more clinical investigations directly related to PCa detection (prostate ultrasounds and biopsies) during the 4 years prior to PCa diagnosis, compared to patients with aggressive PCa, which may have contributed to the early detection of PCa.