Cardiomyocyte Autophagia and Morphological Alterations in the Left Ventricular Myocardium during Acute Focal Ischemia

In experiments on rabbits we evaluated the intensity of cardiomyocyte autophagia by the level beclin-1 protein and morphology of the left ventricular myocardium on days 1, 3, and 5 after the onset of focal ischemia caused by ligation of the descending branch of the left coronary artery. The morpholo...

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Published inBulletin of experimental biology and medicine Vol. 160; no. 3; pp. 398 - 400
Main Authors Blagonravov, M. L., Korshunova, A. Yu, Azova, M. M., Bondar’, S. A., Frolov, V. A.
Format Journal Article
LanguageEnglish
Published New York Springer US 2016
Springer
Springer Nature B.V
Subjects
Animals
Apoptosis Regulatory Proteins - metabolism
Autophagy - physiology
Biomedical and Life Sciences
Biomedicine
Cell Biology
Internal Medicine
Ischemia
Laboratory Medicine
Male
Myocardial Ischemia - metabolism
Myocardial Ischemia - pathology
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - pathology
Pathology
Rabbits
Ventricular Function, Left - physiology
autophagia
focal ischemia
myocardium
beclin-1
cardiomyocyte
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Summary:In experiments on rabbits we evaluated the intensity of cardiomyocyte autophagia by the level beclin-1 protein and morphology of the left ventricular myocardium on days 1, 3, and 5 after the onset of focal ischemia caused by ligation of the descending branch of the left coronary artery. The morphological alterations in the left ventricular myocardium were accompanied by intensification of cardiomyocyte autophagia, which attained maximum on postligation day 1.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3180-1