Detection of Gold Nanoparticles in Rat Organs by Transmission Electron Microscopy

• Published in: Bulletin of experimental biology and medicine Vol. 160; no. 6; pp. 817 - 822
• Main Authors: Platonova, T. A., Pridvorova, S. M., Zherdev, A. V., Gmoshinskii, I. V., Vasilevskaya, L. S., Dzantiev, B. B.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2016; Springer; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Biotechnologies; Cell Biology; Chemical properties; Electron microscopy; Endoplasmic Reticulum - drug effects; Endoplasmic Reticulum - pathology; Gold - pharmacokinetics; Gold - toxicity; Internal Medicine; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Intestine, Small - drug effects; Intestine, Small - metabolism; Intestine, Small - pathology; Laboratory Medicine; Liver; Liver - drug effects; Liver - metabolism; Liver - pathology; Male; Metal Nanoparticles - toxicity; Microscopy, Electron, Transmission; Nanoparticles; Pathology; Rats, Wistar; Spleen - drug effects; Spleen - metabolism; Spleen - pathology; Tissue Distribution; gold nanoparticles; electron microscopy; rat organ tissues
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-016-3318-1

The effects of water-dispersed gold nanoparticles (8.0±0.9 nm in diameter) on the rat small intestinal mucosa and Peyer plaques, liver, and spleen were studied by electron microscopy. Water-dispersed gold nanoparticles injected into isolated intestinal loop not only accumulated in the small intestinal mucosa and Peyer plaques, but also penetrated into other organs, e.g . liver and spleen. Ultrastructural changes in the cells (hyperplasia of endoplasmic reticulum) were detected in the studied organs.