Opiate antagonists and the modification of heroin self-administration behavior in man: an experimental study

The heroin self-administration behavior of 8 inpatient heroin addicts was examined for 10 days under blocked (i.e., following ingestion of narcotic antagonists--naloxone or naltrexone) and unblocked (no antagonist) conditions. In the unblocked state, subjects injected all the available heroin, but t...

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Bibliographic Details
Published inInternational journal of the addictions Vol. 11; no. 3; p. 485
Main Authors Altman, J L, Meyer, R E, Mirin, S M, McNamee, H B
Format Journal Article
LanguageEnglish
Published United States 1976
Subjects
Adult
Aftercare
Behavior Therapy
Boston
Conditioning, Operant
Evaluation Studies as Topic
Heroin Dependence - rehabilitation
Humans
Male
Middle Aged
Naloxone - therapeutic use
Naltrexone - therapeutic use
Narcotic Antagonists - therapeutic use
Research Design
Satiation
Token Economy
Boston
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Summary:The heroin self-administration behavior of 8 inpatient heroin addicts was examined for 10 days under blocked (i.e., following ingestion of narcotic antagonists--naloxone or naltrexone) and unblocked (no antagonist) conditions. In the unblocked state, subjects injected all the available heroin, but they ceased heroin use almost completely following antagonist administration. Possible explanations for these results are discussed along with their implications for treatment.
ISSN:0020-773X
DOI:10.3109/10826087609056165