Elimination of paraquat

There is a striking discrepancy between the efficacy of the kidneys, haemodialysis and haemoperfusion in removing paraquat from the body and the poor prognosis of paraquat poisoning even when the blood and urine concentrations (which are good indices of concentrations in lung and other tissues) are...

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Published inHuman & experimental toxicology Vol. 6; no. 1; pp. 63 - 67
Main Authors Bismuth, C, Scherrmann, J M, Garnier, R, Baud, F J, Pontal, P G
Format Journal Article
LanguageEnglish
Published England 01.01.1987
Subjects
Animals
Hemoperfusion
Humans
Kidney - metabolism
Paraquat - metabolism
Paraquat - poisoning
Renal Dialysis
Tissue Distribution
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Summary:There is a striking discrepancy between the efficacy of the kidneys, haemodialysis and haemoperfusion in removing paraquat from the body and the poor prognosis of paraquat poisoning even when the blood and urine concentrations (which are good indices of concentrations in lung and other tissues) are very low. Extracorporeal elimination techniques have been used world-wide in paraquat poisoning. Do they remove paraquat effectively? Certainly. Do they increase the survival rate? Probably not. The reason being that when these techniques of elimination are initiated, potentially lethal concentrations of paraquat have already been attained in the highly vascular tissues of vital organs and in pneumocytes. The data presented here suggest that the successful treatment of paraquat poisoning will not be achieved by modification of toxicokinetics.
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ISSN:0144-5952
0960-3271
DOI:10.1177/096032718700600110