Changes in Activity of Cysteine Cathepsins B and L in Brain Structures of Mice with Aggressive and Depressive-Like Behavior Formed under Conditions of Social Stress

• Published in: Bulletin of experimental biology and medicine Vol. 164; no. 4; pp. 425 - 429
• Main Authors: Zhanaeva, S. Ya, Rogozhnikova, A. A., Alperina, E. L., Gevorgyan, M. M., Idov, G. V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2018; Springer; Springer Nature B.V
• Subjects: Aggression - psychology; Aggressive behavior; Agonistic Behavior; Analysis; Animal behavior; Animals; Behavior; Biomedical and Life Sciences; Biomedicine; Brain; Cathepsin B - metabolism; Cathepsin L; Cathepsin L - metabolism; Cathepsins; Caudate nucleus; Caudate Nucleus - drug effects; Caudate Nucleus - enzymology; Caudate Nucleus - immunology; Caudate Nucleus - physiopathology; Cell Biology; Cortex (frontal); Cysteine; Cystine; Depression - enzymology; Depression - immunology; Depression - physiopathology; Enzymes; Frontal Lobe - drug effects; Frontal Lobe - enzymology; Frontal Lobe - immunology; Frontal Lobe - physiopathology; Hippocampus; Hippocampus - drug effects; Hippocampus - enzymology; Hippocampus - immunology; Hippocampus - physiopathology; Hypothalamus; Hypothalamus - drug effects; Hypothalamus - enzymology; Hypothalamus - immunology; Hypothalamus - physiopathology; Immune system; Internal Medicine; Laboratory Medicine; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Male; Mice; Mice, Inbred C57BL; Organ Specificity; Pathology; Primates; Rodents; Social interactions; Stress (Psychology); Stress, Psychological - enzymology; Stress, Psychological - immunology; Stress, Psychological - physiopathology; Thiols; cathepsins B and L; aggressive and depressive-like behavior; chronic social stress; brain structures
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-018-4004-2

We studied activity of lysosomal cysteine proteases, cathepsins B and L, in brain structures (frontal cortex, caudate nucleus, hippocampus, and hypothalamus) of C57Bl/6J mice with aggressive and depressive-like behavior formed under conditions of chronic social stress (repeated experience of victories and defeats within 20 days). Mice with depressive-like behavior showed increased activity of cathepsin В in the hypothalamus and nucleus caudatus and increased activity of cathepsin L in the hippocampus compared to control animals not subjected to agonistic confrontations. In mice with aggressive behavior, protease activity in the studied brain structures was not changed. In 4 h after immune system activation with LPS (250 μg/kg), cathepsin L activity in the hippocampus of control mice increased in comparison with mice receiving saline. In contrast to control animals, LPS caused a decrease in activity of the enzyme in the caudate nucleus and frontal cortex of aggressive mice and in the hippocampus of mice with depressive-like behavior.