Transcranial Focused Ultrasound Neuromodulation: A Review of the Excitatory and Inhibitory Effects on Brain Activity in Human and Animals

Non-invasive neuromodulation technology is important for the treatment of brain diseases. The effects of focused ultrasound on neuronal activity have been investigated since the 1920s. Low intensity transcranial focused ultrasound (tFUS) can exert non-destructive mechanical pressure effects on cellu...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in human neuroscience Vol. 15; p. 749162
Main Authors Zhang, Tingting, Pan, Na, Wang, Yuping, Liu, Chunyan, Hu, Shimin
Format Journal Article
LanguageEnglish
Published Lausanne Frontiers Research Foundation 28.09.2021
Frontiers Media S.A
Subjects
Ablation
animal
Animals
Brain research
Cavitation
Cell membranes
human
Ion channels
Mental disorders
Neurodegenerative diseases
Neuromodulation
Neuroscience
non-invasive brain stimulation
Peripheral nerves
Reflexes
Thalamus
Thermal injury
transcranial focused ultrasound
Ultrasonic imaging
Ultrasound
Online AccessGet full text

Cover

More Information
Summary:Non-invasive neuromodulation technology is important for the treatment of brain diseases. The effects of focused ultrasound on neuronal activity have been investigated since the 1920s. Low intensity transcranial focused ultrasound (tFUS) can exert non-destructive mechanical pressure effects on cellular membranes and ion channels and has been shown to modulate the activity of peripheral nerves, spinal reflexes, the cortex, and even deep brain nuclei, such as the thalamus. It has obvious advantages in terms of security and spatial selectivity. This technology is considered to have broad application prospects in the treatment of neurodegenerative disorders and neuropsychiatric disorders. This review synthesizes animal and human research outcomes and offers an integrated description of the excitatory and inhibitory effects of tFUS in varying experimental and disease conditions.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Edited by: Jiaojian Wang, University of Electronic Science and Technology of China, China
Reviewed by: Xiaojing Long, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS), China; Li Wang, Beijing Institute of Technology, China
This article was submitted to Brain Imaging and Stimulation, a section of the journal Frontiers in Human Neuroscience
ISSN:1662-5161
1662-5161
DOI:10.3389/fnhum.2021.749162