Opening of the blood-brain barrier preceding cortical edema in a severe attack of FHM type II
The authors report a patient with familial hemiplegic migraine type II who developed a long-lasting attack including fever, right-sided hemiplegia, aphasia, and coma. Quantitative analysis of early gadolinium-enhanced MRI revealed a mild but significant left-hemispheric blood-brain barrier (BBB) ope...
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Published in | Neurology Vol. 64; no. 12; p. 2145 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
28.06.2005
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Subjects | |
Online Access | Get more information |
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Summary: | The authors report a patient with familial hemiplegic migraine type II who developed a long-lasting attack including fever, right-sided hemiplegia, aphasia, and coma. Quantitative analysis of early gadolinium-enhanced MRI revealed a mild but significant left-hemispheric blood-brain barrier (BBB) opening limited to the cortex and preceding cortical edema. The findings suggest that the delayed cortical edema was vasogenic in the severe migraine aura variant of this ATP1A2 mutation carrier. |
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ISSN: | 1526-632X |
DOI: | 10.1212/01.wnl.0000176298.63840.99 |