A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing Antibodies

• Published in: Journal of Virology Vol. 83; no. 17; pp. 8451 - 8462
• Main Authors: PEJCHAL, Robert, GACH, Johannes S, BRUNEL, Florence M, CARDOSO, Rosa M, STANFIELD, Robyn L, DAWSON, Philip E, BURTON, Dennis R, ZWICK, Michael B, WILSON, Ian A
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.09.2009; American Society for Microbiology (ASM)
• Subjects: Allosteric Regulation; Antibodies, Monoclonal - chemistry; Antibodies, Monoclonal - immunology; Biological and medical sciences; Crystallography, X-Ray; Fundamental and applied biological sciences. Psychology; HIV Antibodies - chemistry; HIV Antibodies - immunology; HIV Envelope Protein gp41 - chemistry; HIV-1 - chemistry; HIV-1 - immunology; Human immunodeficiency virus 1; Humans; Immunoglobulin Fab Fragments - chemistry; Immunoglobulin Fab Fragments - immunology; Microbiology; Miscellaneous; Models, Molecular; Neutralization Tests; Protein Conformation; Protein Structure, Quaternary; Virology; Virus-Cell Interactions; Virus; Antigenic determinant; Retroviridae; Human immunodeficiency virus; Lentivirus; Neutralizing antibody; Conformation; Virology
• ISSN: 0022-538X; 1098-5514
• DOI: 10.1128/JVI.00685-09

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