Aging and diabetic retinopathy: Inherently intertwined pathophysiological processes

• Published in: Experimental gerontology Vol. 175; p. 112138
• Main Authors: Li, Qingbo, Wang, Mengqi, Li, Xiaorong, Shao, Yan
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.05.2023; Elsevier
• Subjects: Advanced glycation end products; Aged; Aging; Cytokine; Diabetes Mellitus; Diabetic retinopathy; Diabetic Retinopathy - complications; Diabetic Retinopathy - epidemiology; Humans; Longevity; Metabolism; Oxidative stress; Prevalence; Risk Factors; Aging; Diabetic retinopathy; Oxidative stress; Advanced glycation end products; Metabolism; Cytokine
• ISSN: 0531-5565; 1873-6815; 1873-6815
• DOI: 10.1016/j.exger.2023.112138

Diabetic retinopathy (DR) is a leading cause of blindness worldwide and a costly complication of diabetes mellitus (DM). DR severity is associated with DM duration; thus, DR has become more devastating to individuals and healthcare systems owing to the aging population and the significantly increased human lifespan. Aging is an irreversible cellular state characterized by long-term stagnation of the cell cycle from excessive stress or damage. Furthermore, aging plays a critical role in developing age-related diseases, but its effects (direct or indirect) on DR development remain considerably understudied. Nonetheless, some studies have demonstrated that aging-related degeneration and DR development share common risk factors, which helps explain the increased prevalence of DR and visual impairment in the elderly population. This review aims to provide some conceptual insight into aging and DR development, two intertwined pathophysiological processes, and discusses potential therapeutic strategies for DR, including prevention and treatment, during this era of longevity. •Diabetic retinopathy (DR) and biological aging are closely related to extracellular environment.•Senescence plays important role in age-related diseases, but its contribution to the development of DR is still undervalued.•The aging-related degeneration and DR development shared some common risk factors.•Aging-related metabolic disorder accelerates DR development in the aging population.