Vascular endothelial growth factor association with angiopoietin 1 promotes improvement in ventricular function after ischemic cardiomyopathy induced in mini pigs

• Published in: Acta cirurgica brasileira Vol. 33; no. 4; pp. 386 - 395
• Main Authors: Oliveira, André Lacerda de Abreu, Scheffer, Jussara Peters, Markoski, Melissa, Koche, Andreia, Balbinot, Alexsandra, Antunes, Fernanda, Kalil, Renato
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 01.04.2018
• Subjects: Angiopoietin-1 - therapeutic use; Animals; Cell- and Tissue-Based Therapy - methods; Disease Models, Animal; Echocardiography; Genetic Therapy; Genetic Therapy - methods; Hemodynamics - physiology; Myocardial Infarction; Myocardial Infarction - pathology; Myocardial Infarction - physiopathology; Myocardial Infarction - therapy; Necrosis; Neovascularization, Physiologic; Reproducibility of Results; Swine; Swine, Miniature; Tissue; Treatment Outcome; Vascular Endothelial Growth Factor A - therapeutic use; Ventricular Function - physiology; Wound Healing

To investigate the safety and clinical, hemodynamic and tissue improvement ability in mini pigs undergoing cell and gene therapy for the treatment of acute myocardial infarction. Thirty-two mini pigs Br1 lineage, 12 months old, undergoing induction of acute myocardial infarction by occlusion of the...