Role of the Dopaminergic System in the Striatum and Its Association With Functional Recovery or Rehabilitation After Brain Injury

Disabilities are estimated to occur in approximately 2% of survivors of traumatic brain injury (TBI) worldwide, and disability may persist even decades after brain injury. Facilitation or modulation of functional recovery is an important goal of rehabilitation in all patients who survive severe TBI....

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Published inFrontiers in neuroscience Vol. 15; p. 693404
Main Authors Verduzco-Mendoza, Antonio, Carrillo-Mora, Paul, Avila-Luna, Alberto, Gálvez-Rosas, Arturo, Olmos-Hernández, Adriana, Mota-Rojas, Daniel, Bueno-Nava, Antonio
Format Journal Article
LanguageEnglish
Published Lausanne Frontiers Research Foundation 24.06.2021
Frontiers Media S.A
Subjects
corticostriatal pathway
dopamine
Dopamine receptors
Dosage
Drugs
functional recovery
Ganglia
Localization
Neostriatum
Neuroscience
Neurotransmission
Physical characteristics
Receptor mechanisms
Recovery (Medical)
Recovery of function
Rehabilitation
Traumatic brain injury
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Summary:Disabilities are estimated to occur in approximately 2% of survivors of traumatic brain injury (TBI) worldwide, and disability may persist even decades after brain injury. Facilitation or modulation of functional recovery is an important goal of rehabilitation in all patients who survive severe TBI. However, this recovery tends to vary among patients because it is affected by the biological and physical characteristics of the patients; the types, doses, and application regimens of the drugs used; and clinical indications. In clinical practice, diverse dopaminergic drugs with various dosing and application procedures are used for TBI. Previous studies have shown that dopamine (DA) neurotransmission is disrupted following moderate to severe TBI and have reported beneficial effects of drugs that affect the dopaminergic system. However, the mechanisms of action of dopaminergic drugs have not been completely clarified, partly because dopaminergic receptor activation can lead to restoration of the pathway of the corticobasal ganglia after injury in brain structures with high densities of these receptors. This review aims to provide an overview of the functionality of the dopaminergic system in the striatum and its roles in functional recovery or rehabilitation after TBI.
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This article was submitted to Neuropharmacology, a section of the journal Frontiers in Neuroscience
Edited by: Santiago Perez-Lloret, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
Reviewed by: Yoland Smith, Emory University, United States; Harumasa Takano, National Center of Neurology and Psychiatry, Japan
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2021.693404